This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sundell, H. W. Articles by Stahlman, M. T. Search for Related Content PubMed PubMed Citation Articles by Sundell, H. W. Articles by Stahlman, M. T.

American Journal of Pathology, Vol 100, 707-725, Copyright © 1980 by American Society for Investigative Pathology

REGULAR ARTICLES

Effects of epidermal growth factor on lung maturation in fetal lambs

HW Sundell, ME Gray, FS Serenius, MB Escobedo and MT Stahlman

The ability of epidermal growth factor (EGF) to induce lung maturation was evaluated in fetal and neonatal lambs. EGF was infused (3-5 days) into one member of 10 fetal twin pairs, one member of 2 term twin pairs, and 2 singleton term lambs. All EGF-treated lambs had evidence of epithelial hyperplasia of the conducting airways typical of the EGF effect. With the exception of the most immature pair, the lungs of treated versus control lambs were judged more mature by morphologic criteria by use of light and electron microscopy. None of the 6 premature lambs treated with EGF and allowed to breath showed evidence of hyaline membrane disease, while 3 untreated control lambs developed typical hyaline membranes when delivered by cesarean section after maternal hypotension. All untreated control animals showed more severe clinical symptoms of respiratory distress than did the EGF-treated animals.

This article has been cited by other articles:

				A. Benachi, J.-M. Jouannic, A.-M. Barlier-Mur, B. Chailley-Heu, and J. R. Bourbon Surfactant phospholipids and proteins are increased in fetal sheep with pulmonary hypertension secondary to fetal systemic arteriovenous fistula Am J Physiol Lung Cell Mol Physiol, March 1, 2005; 288(3): L562 - L568. [Abstract] [Full Text] [PDF]

				J. Sanchez-Esteban, Y. Wang, P. A. Gruppuso, and L. P. Rubin Mechanical Stretch Induces Fetal Type II Cell Differentiation Via an Epidermal Growth Factor Receptor-Extracellular-Regulated Protein Kinase Signaling Pathway Am. J. Respir. Cell Mol. Biol., January 1, 2004; 30(1): 76 - 83. [Abstract] [Full Text] [PDF]

				D. J. Foster, X. Yan, D. J. Bellotto, O. W. Moe, H. K. Hagler, A. S. Estrera, and C. C. W. Hsia Expression of epidermal growth factor and surfactant proteins during postnatal and compensatory lung growth Am J Physiol Lung Cell Mol Physiol, November 1, 2002; 283(5): L981 - L990. [Abstract] [Full Text] [PDF]

				J. W. Henck, J. F. Reindel, and J. A. Anderson Growth and Development in Rats Given Recombinant Human Epidermal Growth Factor1-48 as Neonates Toxicol. Sci., July 1, 2001; 62(1): 80 - 91. [Abstract] [Full Text] [PDF]

				C. E. L. Dammann, S. M. Ramadurai, D. D. McCants, L. D. Pham, and H. C. Nielsen Androgen Regulation of Signaling Pathways in Late Fetal Mouse Lung Development Endocrinology, August 1, 2000; 141(8): 2923 - 2929. [Abstract] [Full Text] [PDF]

				J. M. Klein, T. A. McCarthy, J. M. Dagle, and J. M. Snyder Antisense Inhibition of Epidermal Growth Factor Receptor Decreases Expression of Human Surfactant Protein A Am. J. Respir. Cell Mol. Biol., June 1, 2000; 22(6): 676 - 684. [Abstract] [Full Text]

				H. J PORTER Pulmonary hypoplasia Arch. Dis. Child. Fetal Neonatal Ed., September 1, 1999; 81(2): 81F - 83. [Full Text]

				N. Chelly, O.-B. Mouhieddine-Gueddiche, A.-M. Barlier-Mur, B. Chailley-Heu, and J. R. Bourbon Keratinocyte Growth Factor Enhances Maturation of Fetal Rat Lung Type II Cells Am. J. Respir. Cell Mol. Biol., March 1, 1999; 20(3): 423 - 432. [Abstract] [Full Text]

				Y. Goto, Y. Noguchi, A. Nomura, T. Sakamoto, Y. Ishii, S. Bitoh, C. Picton, Y. Fujita, T. Watanabe, S. Hasegawa, et al. In Vitro Reconstitution of the Tracheal Epithelium Am. J. Respir. Cell Mol. Biol., February 1, 1999; 20(2): 312 - 318. [Abstract] [Full Text]

				J. I. Sznajder, K. M. Ridge, D. B. Yeates, J. Ilekis, and W. Olivera Epidermal growth factor increases lung liquid clearance in rat lungs J Appl Physiol, September 1, 1998; 85(3): 1004 - 1010. [Abstract] [Full Text] [PDF]

				C. E. L. Dammann and H. C. Nielsen Regulation of the Epidermal Growth Factor Receptor in Fetal Rat Lung Fibroblasts during Late Gestation Endocrinology, April 1, 1998; 139(4): 1671 - 1677. [Abstract] [Full Text] [PDF]

				J. M. Klein, L. J. Dewild, and T. A. McCarthy Effect of tyrosine kinase inhibition on surfactant protein A gene expression during human lung development Am J Physiol Lung Cell Mol Physiol, April 1, 1998; 274(4): L542 - L551. [Abstract] [Full Text] [PDF]

				A. A. Hislop, R. R. Lee, C. G. A. McGregor, and S. G. Haworth Lung Growth After Transplantation Of An Adult Lobe Of Lung Into A Juvenile Rat J. Thorac. Cardiovasc. Surg., March 1, 1998; 115(3): 644 - 651. [Abstract] [Full Text] [PDF]

				E J Kelly, S J Newell, K G Brownlee, S M Farmery, C Cullinane, W A Reid, P Jackson, S F Gray, J N Primrose, and M Lagopoulos Role of epidermal growth factor and transforming growth factor alpha  in the developing stomach Arch. Dis. Child. Fetal Neonatal Ed., May 1, 1997; 76(3): 158F - 162. [Abstract] [Full Text]

				M. W. Varner, G. A. Dildy, C. Hunter, D. J. Dudley, S. L. Clark, and M. D. Mitchell Amniotic Fluid Epidermal Growth Factor Levels in Normal and Abnormal Pregnancies Reproductive Sciences, January 1, 1996; 3(1): 17 - 19. [Abstract] [PDF]

				E. Durban, P. Nagpala, P. Barreto, and E Durban Emergence of salivary gland cell lineage diversity suggests a role for androgen-independent epidermal growth factor receptor signaling J. Cell Sci., January 6, 1995; 108(6): 2205 - 2212. [Abstract] [PDF]