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American Journal of Pathology, Vol 101, 365-374, Copyright © 1980 by American Society for Investigative Pathology

REGULAR ARTICLES

A study of the origin of pulmonary macrophages using the Chediak- Higashi marker

KJ Johnson, PA Ward, G Striker and R Kunkel

Using bone marrow reconstitution techniques with cells bearing the Chediak-Higashi marker, the authors have been able to demonstrate in mice that both interstitial and intraalveolar macrophages of the lung are derived from bone marrow precursor cells. The morphologic approach (transmission electron microscopy) employed in this study provides direct evidence and confirmation of earlier reports, in which entirely different techniques were used to study cell traffic in the lung. The use of the Chediak-Higashi marker has great advantages over other more cumbersome and difficult techniques.

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