help button home button Am J Pathol ASIP 2008 Summer Academy, Molecular Methcanisms of Human Disease: Injury, Inflammation, and Tissue Repair
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Powers, J. M.
Right arrow Articles by Schaumburg, H. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Powers, J. M.
Right arrow Articles by Schaumburg, H. H.

American Journal of Pathology, Vol 102, 90-98, Copyright © 1981 by American Society for Investigative Pathology

REGULAR ARTICLES

The testis in adreno-leukodystrophy

JM Powers and HH Schaumburg

Testicular tissue from 7 juvenile and 6 adult patients with adreno- leukodystrophy (ALD) or its adrenomyeloneuropathic (AMN) variant was examined by light and electron microscopy. The seminiferous tubules of the men exhibited hypocellularity, maturation arrest, or Sertoli cells and spermatogonia only. Ultrastructural examination of these specimens revealed vacuolation of Sertoli cell endoplasmic reticulum. Germ cells also demonstrated vacuolation and necrosis, accompanied by slight tubular atrophy and thickening of the tunica propria. Fibrosis or proteinaceous fluid was observed in the interstitium. The tissue of 5 men and 2 boys contained Leydig cells with cytoplasmic striations, which were detectable with the light microscope. A decrease in the number of Leydig cells was noted in some men. All specimens displayed pathognomonic lamellas and lamellar-lipid profiles in mature, immature, or precursor Leydig cells at the ultrastructural level. The Leydig cell demonstrated the primary morphologic defect in the ALD testis; damage to Sertoli cells appeared to be the initial lesion of seminiferous tubules.


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
A. Nenicu, G. H Luers, W. Kovacs, M. Bergmann, and E. Baumgart-Vogt
Peroxisomes in Human and Mouse Testis: Differential Expression of Peroxisomal Proteins in Germ Cells and Distinct Somatic Cell Types of the Testis
Biol Reprod, December 1, 2007; 77(6): 1060 - 1072.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Huyghe, H. Schmalbruch, K. De Gendt, G. Verhoeven, F. Guillou, P. P. Van Veldhoven, and M. Baes
Peroxisomal Multifunctional Protein 2 Is Essential for Lipid Homeostasis in Sertoli Cells and Male Fertility in Mice
Endocrinology, May 1, 2006; 147(5): 2228 - 2236.
[Abstract] [Full Text] [PDF]

Home page
 CMAJHome page
M. Spurek, R. Taylor-Gjevre, S. Van Uum, and H. M. Khandwala
Adrenomyeloneuropathy as a cause of primary adrenal insufficiency and spastic paraparesis
Can. Med. Assoc. J., October 26, 2004; 171(9): 1073 - 1077.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
B. M van Geel, J. Assies, R. J A Wanders, and P. G Barth
X linked adrenoleukodystrophy: clinical presentation, diagnosis, and therapy
J. Neurol. Neurosurg. Psychiatry, July 1, 1997; 63(1): 4 - 14.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1981 by the American Society for Investigative Pathology.