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American Journal of Pathology, Vol 102, 396-402, Copyright © 1981 by American Society for Investigative Pathology

REGULAR ARTICLES

Electrophoretically pure mouse interferon inhibits growth, induces liver and kidney lesions, and kills suckling mice

I Gresser, M Aguet, L Morel-Maroger, D Woodrow, F Puvion-Dutilleul, JC Guillon and C Maury

Suckling Swiss mice were injected daily for 8 days with either electrophoretically pure (EP) mouse interferon (s.a. 4.7 x 10(8) units/mg protein), major impurities obtained in the course of purification, or partially purified mouse interferon (s.a. 1.3 x 10(7) units/mg protein). Only EP or partially purified interferon inhibited growth, induced liver and kidney lesions, and killed mice. The authors conclude that interferon itself is responsible for these effects.

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