This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Issekutz, T. B. Articles by Movat, H. Z. Search for Related Content PubMed PubMed Citation Articles by Issekutz, T. B. Articles by Movat, H. Z.

American Journal of Pathology, Vol 103, 47-55, Copyright © 1981 by American Society for Investigative Pathology

REGULAR ARTICLES

The in vivo quantitation and kinetics of monocyte migration into acute inflammatory tissue

TB Issekutz, AC Issekutz and HZ Movat

Mononuclear leukocytes isolated from the blood of rabbits, were labeled with 51Cr and returned to the animal intravenously. 51Cr-labeled monocytes disappeared from the blood with a half-life of 39.0 +/- 2.51 hours. Numerous acute inflammatory lesions were produced by the intradermal injection of Escherichia coli into the skin of the back of a rabbit. The animal was sacrificed after 1 hour, and the radioactivity in each lesion was determined. Monocyte accumulation was substantial by the time a lesion was 1 hour old. The maximum rate of accumulation occurred at 3--4 hours, and monocytes continued to enter the lesions at 25% of the maximal rate for at least 24 hours. Monocytes initially migrate into bacterial inflammatory sites simultaneously with neutrophils and histologically become the predominant cell type after 12 hours because they continue to migrate into these lesions long after neutrophils have stopped. The kinetics of monocyte migration is related to other aspects of inflammation.

This article has been cited by other articles:

				A. V. Woodard-Grice, A. C. McBrayer, J. K. Wakefield, Y. Zhuo, and S. L. Bellis Proteolytic Shedding of ST6Gal-I by BACE1 Regulates the Glycosylation and Function of {alpha}4{beta}1 Integrins J. Biol. Chem., September 26, 2008; 283(39): 26364 - 26373. [Abstract] [Full Text] [PDF]

				Y. Li, A. Karlin, J. D. Loike, and S. C. Silverstein Determination of the Critical Concentration of Neutrophils Required to Block Bacterial Growth in Tissues J. Exp. Med., September 7, 2004; 200(5): 613 - 622. [Abstract] [Full Text] [PDF]

				Y. Goto, J. C. Hogg, B. Whalen, C.-H. Shih, H. Ishii, and S. F. van Eeden Monocyte Recruitment into the Lungs in Pneumococcal Pneumonia Am. J. Respir. Cell Mol. Biol., May 1, 2004; 30(5): 620 - 626. [Abstract] [Full Text] [PDF]

				Y. Goto, J. C. Hogg, T. Suwa, K. B. Quinlan, and S. F. van Eeden A novel method to quantify the turnover and release of monocytes from the bone marrow using the thymidine analog 5'-bromo-2'-deoxyuridine Am J Physiol Cell Physiol, August 1, 2003; 285(2): C253 - C259. [Abstract] [Full Text] [PDF]

				M. J. VanWijk, E. VanBavel, A. Sturk, and R. Nieuwland Microparticles in cardiovascular diseases Cardiovasc Res, August 1, 2003; 59(2): 277 - 287. [Abstract] [Full Text] [PDF]

				I. Singh, K.G. Burnand, M. Collins;, A. Luttun, D. Collen, B. Boelhouwer;, and A. Smith Failure of Thrombus to Resolve in Urokinase-Type Plasminogen Activator Gene-Knockout Mice: Rescue by Normal Bone Marrow-Derived Cells Circulation, February 18, 2003; 107(6): 869 - 875. [Abstract] [Full Text] [PDF]

				B. Ristevski, A. J. Young, L. Dudler, R. N. P. Cahill, W. Kimpton, E. Washington, and J. B. Hay Tracking dendritic cells: use of an in situ method to label all blood leukocytes Int. Immunol., February 1, 2003; 15(2): 159 - 165. [Abstract] [Full Text] [PDF]

				J. Alroy, S. Sabnis, and J. B. Kopp Renal Pathology in Fabry Disease J. Am. Soc. Nephrol., June 1, 2002; 13(90002): S134 - 138. [Full Text] [PDF]

				T. M. Carlos Leukocyte recruitment at sites of tumor: dissonant orchestration J. Leukoc. Biol., August 1, 2001; 70(2): 171 - 184. [Abstract] [Full Text] [PDF]

				O. P. Barry, M. G. Kazanietz, D. Pratico, and G. A. FitzGerald Arachidonic Acid in Platelet Microparticles Up-regulates Cyclooxygenase-2-dependent Prostaglandin Formation via a Protein Kinase C/Mitogen-activated Protein Kinase-dependent Pathway J. Biol. Chem., March 12, 1999; 274(11): 7545 - 7556. [Abstract] [Full Text] [PDF]

				H. Koga, K. Aoyagi, T. Matsumoto, M. Iida, and M. Fujishima Experimental enteropathy in athymic and euthymic rats: synergistic role of lipopolysaccharide and indomethacin Am J Physiol Gastrointest Liver Physiol, March 1, 1999; 276(3): G576 - G582. [Abstract] [Full Text] [PDF]

				M. Colden-Stanfield and E. K. Gallin Modulation of K+ currents in monocytes by VCAM-1 and E-selectin on activated human endothelium Am J Physiol Cell Physiol, July 1, 1998; 275(1): C267 - C277. [Abstract] [Full Text] [PDF]

				M.-J. Sanz, A. Hartnell, P. Chisholm, C. Williams, D. Davies, V. B. Weg, M. Feldmann, M. A. Bolanowski, R. R. Lobb, and S. Nourshargh Tumor Necrosis Factor alpha -Induced Eosinophil Accumulation in Rat Skin Is Dependent on alpha 4 Integrin/Vascular Cell Adhesion Molecule-1 Adhesion Pathways Blood, November 15, 1997; 90(10): 4144 - 4152. [Abstract] [Full Text] [PDF]

				D. Steinberg, J. C. Khoo, C. K. Glass, W. Palinski, and F. Almazan A new approach to determining the rates of recruitment of circulating leukocytes into tissues: Application to the measurement of leukocyte recruitment into atherosclerotic lesions PNAS, April 15, 1997; 94(8): 4040 - 4044. [Abstract] [Full Text] [PDF]