This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kauffman, S. L. Search for Related Content PubMed PubMed Citation Articles by Kauffman, S. L.

American Journal of Pathology, Vol 103, 174-180, Copyright © 1981 by American Society for Investigative Pathology

REGULAR ARTICLES

Histogenesis of the papillary Clara cell adenoma

SL Kauffman

Mouse lung adenomas have two characteristic histologic patterns, alveolar and bronchiolar or papillary. Differences in biologic behavior have been noted in tumors of different histologic form, in that papillary tumors were said to grow faster and become larger and possibly malignant. Progressive development from the alveolar to the papillary tumors has been proposed, involving a step-wise transformation from benign to malignant tumors. The author recently presented evidence from ultrastructural studies that the different histologic patterns were related to the cell of origin; the bronchiolar tumors consisted of Clara cells, while the alveolar tumors were made up of Type II alveolar epithelium. In the present study, designed to evaluate the histologic patterns of tumors during their development, multiple lung adenomas were induced in fetal Bagg-Webster mice on the sixteenth day of gestation by a single transplacental exposure to ethyl- nitrosourea. The animals were killed from the seventh postnatal day to 185 days of age; their tumors were counted and categorized histologically. Analysis of serial-step sections of the right lower lobes of young postnatal mice showed tumors with either an alveolar (37%) or a bronchiolar pattern (63%). Two forms of the latter were recognized, tubular and papillary. Between Day 80 and Day 186 papillary adenomas increased, tubular tumors decreased, and alveolar adenomas remained relatively constant in number. At the end of the 6-month observation period the overall proportion of alveolar and Clara cell tumors was similar to that found in the first 3 weeks of life. These data support the concept that alveolar and papillary tumors arise from different cell lines, the papillary tumors exclusively from Clara cells.

This article has been cited by other articles:

				D. Dixon, R. A. Herbert, G. E. Kissling, A. E. Brix, R. A. Miller, and R. R. Maronpot Summary of Chemically Induced Pulmonary Lesions in the National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies Toxicol Pathol, April 1, 2008; 36(3): 428 - 439. [Abstract] [Full Text] [PDF]

				X.-H. Pei, F. Bai, M. D. Smith, and Y. Xiong p18Ink4c Collaborates with Men1 to Constrain Lung Stem Cell Expansion and Suppress Non-Small-Cell Lung Cancers Cancer Res., April 1, 2007; 67(7): 3162 - 3170. [Abstract] [Full Text] [PDF]

				A. K. Bauer, A. M. Malkinson, and S. R. Kleeberger Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities Am J Physiol Lung Cell Mol Physiol, October 1, 2004; 287(4): L685 - L703. [Abstract] [Full Text] [PDF]

				A. Yu. Nikitin, A. Alcaraz, M. R. Anver, R. T. Bronson, R. D. Cardiff, D. Dixon, A. E. Fraire, E. W. Gabrielson, W. T. Gunning, D. C. Haines, et al. Classification of Proliferative Pulmonary Lesions of the Mouse: Recommendations of the Mouse Models of Human Cancers Consortium Cancer Res., April 1, 2004; 64(7): 2307 - 2316. [Abstract] [Full Text] [PDF]

				M. A. Pereira, Y. Li, W. T. Gunning, P. M. Kramer, F. Al-Yaqoub, R. A. Lubet, V. E. Steele, E. Szabo, and L. Tao Prevention of mouse lung tumors by budesonide and its modulation of biomarkers Carcinogenesis, July 1, 2002; 23(7): 1185 - 1192. [Abstract] [Full Text] [PDF]

				R. J. Mason, M. Kalina, L. D. Nielsen, A. M. Malkinson, and J. M. Shannon Surfactant Protein C Expression in Urethane-Induced Murine Pulmonary Tumors Am. J. Pathol., January 1, 2000; 156(1): 175 - 182. [Abstract] [Full Text] [PDF]

				M. Schwarz, M. Lee, F. Zhang, J. Zhao, Y. Jin, S. Smith, J. Bhuva, D. Stern, D. Warburton, and V. Starnes EMAP II: a modulator of neovascularization in the developing lung Am J Physiol Lung Cell Mol Physiol, February 1, 1999; 276(2): L365 - L375. [Abstract] [Full Text] [PDF]