| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 103, 191-200, Copyright © 1981 by American Society for Investigative Pathology
REGULAR ARTICLES |
RG Gerrity
A defined role in the atherogenic sequence is proposed for the circulating monocyte. The author has been able to demonstrate a "monocyte clearance system" in which large numbers of circulating monocytes invade the intima of lesion-prone areas in arteries, become phagocytic, and accumulate lipid. A fatty cell lesion results. Once lipid-laden, foam cells migrate back into the bloodstream by crossing the arterial endothelium. The ratio of penetrating monocytes to emerging foam cells decreases as fatty cell lesions develop until a one- to-one ratio is achieved in late fatty cell lesions, which do not progress further. Advanced fibroatherosclerotic plaques in the same animals do not show the same characteristics and have smooth muscle cell involvement. It would appear that advancement of the lesion is at least partially a result of failure of the monocyte clearance system to remove sufficient lipid. The invasion of monocytes and endothelial damage caused by foam cell clearance may, in late fatty lesions, contribute to plaque evolution by introducing growth factors from macrophages and platelets and allowing greater lipid influx. Elucidation of this system was facilitated by the examination of vessels from diet initiation onwards and by the observation of late nonprogressing fatty cell lesions. It is possible that this system exists in other models but has been overlooked by a predilection for the study of advanced lesions that prevails in the literature.
This article has been cited by other articles:
 |
|
 |
|
  E. Shantsila and G. Y.H. Lip Monocytes in Acute Coronary Syndromes Arterioscler Thromb Vasc Biol, October 1, 2009; 29(10): 1433 - 1438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. V. Westhorpe, J. Zhou, N. L. Webster, B. Kalionis, S. R. Lewin, A. Jaworowski, W. A. Muller, and S. M. Crowe Effects of HIV-1 infection in vitro on transendothelial migration by monocytes and monocyte-derived macrophages J. Leukoc. Biol., June 1, 2009; 85(6): 1027 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.A. Berliner and C.C. Hedrick Ross Gerrity, 1945-2008 Arterioscler Thromb Vasc Biol, September 1, 2008; 28(9): e155 - e155. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rajesh, P. Mukhopadhyay, S. Batkai, G. Hasko, L. Liaudet, V. R. Drel, I. G. Obrosova, and P. Pacher Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H610 - H619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. T. Bolick, A. M. Whetzel, M. Skaflen, T. L. Deem, J. Lee, and C. C. Hedrick Absence of the G Protein-Coupled Receptor G2A in Mice Promotes Monocyte/Endothelial Interactions in Aorta Circ. Res., March 2, 2007; 100(4): 572 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Whetzel, D. T. Bolick, S. Srinivasan, T. L. Macdonald, M. A. Morris, K. Ley, and C. C. Hedrick Sphingosine-1 Phosphate Prevents Monocyte/Endothelial Interactions in Type 1 Diabetic NOD Mice Through Activation of the S1P1 Receptor Circ. Res., September 29, 2006; 99(7): 731 - 739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Bolick, S. Srinivasan, A. Whetzel, L. C. Fuller, and C. C. Hedrick 12/15 Lipoxygenase Mediates Monocyte Adhesion to Aortic Endothelium in Apolipoprotein E-Deficient Mice Through Activation of RhoA and NF-{kappa}B Arterioscler Thromb Vasc Biol, June 1, 2006; 26(6): 1260 - 1266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tedgui and Z. Mallat Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways Physiol Rev, April 1, 2006; 86(2): 515 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Tabas Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis: The Importance of Lesion Stage and Phagocytic Efficiency Arterioscler Thromb Vasc Biol, November 1, 2005; 25(11): 2255 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Bolick, A. W. Orr, A. Whetzel, S. Srinivasan, M. E. Hatley, M. A. Schwartz, and C. C. Hedrick 12/15-Lipoxygenase Regulates Intercellular Adhesion Molecule-1 Expression and Monocyte Adhesion to Endothelium Through Activation of RhoA and Nuclear Factor-{kappa}B Arterioscler Thromb Vasc Biol, November 1, 2005; 25(11): 2301 - 2307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Steinberg Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy, part III: mechanistically defining the role of hyperlipidemia J. Lipid Res., October 1, 2005; 46(10): 2037 - 2051. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Virmani, F. D. Kolodgie, A. P. Burke, A. V. Finn, H. K. Gold, T. N. Tulenko, S. P. Wrenn, and J. Narula Atherosclerotic Plaque Progression and Vulnerability to Rupture: Angiogenesis as a Source of Intraplaque Hemorrhage Arterioscler Thromb Vasc Biol, October 1, 2005; 25(10): 2054 - 2061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nasir, E. Guallar, A. Navas-Acien, M. H. Criqui, and J. A.C. Lima Relationship of Monocyte Count and Peripheral Arterial Disease: Results From the National Health and Nutrition Examination Survey 1999-2002 Arterioscler Thromb Vasc Biol, September 1, 2005; 25(9): 1966 - 1971. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kihara, Y. Miyata, M. Furukawa, M. Noguchi, M. Nishikido, S. Koga, and H. Kanetake Predictive value of serum macrophage colony-stimulating factor for development of aortic calcification in haemodialysis patients: a 6 year longitudinal study Nephrol. Dial. Transplant., August 1, 2005; 20(8): 1647 - 1652. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Llodra, V. Angeli, J. Liu, E. Trogan, E. A. Fisher, and G. J. Randolph From the Cover: Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques PNAS, August 10, 2004; 101(32): 11779 - 11784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Srinivasan, D. T. Bolick, M. E. Hatley, R. Natarajan, K. B. Reilly, M. Yeh, C. Chrestensen, T. W. Sturgill, and C. C. Hedrick Glucose Regulates Interleukin-8 Production in Aortic Endothelial Cells through Activation of the p38 Mitogen-activated Protein Kinase Pathway in Diabetes J. Biol. Chem., July 23, 2004; 279(30): 31930 - 31936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. F. Galley and N. R. Webster Physiology of the endothelium Br. J. Anaesth., July 1, 2004; 93(1): 105 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Antonov, F. D. Kolodgie, D. H. Munn, and R. G. Gerrity Regulation of Macrophage Foam Cell Formation by {alpha}V{beta}3 Integrin: Potential Role in Human Atherosclerosis Am. J. Pathol., July 1, 2004; 165(1): 247 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Srinivasan, M. E. Hatley, K. B. Reilly, E. C. Danziger, and C. C. Hedrick Modulation of PPAR{alpha} Expression and Inflammatory Interleukin-6 Production by Chronic Glucose Increases Monocyte/Endothelial Adhesion Arterioscler Thromb Vasc Biol, May 1, 2004; 24(5): 851 - 857. [Abstract] [Full Text]
|
|
|
|
|
|
S. Crowe, T. Zhu, and W. A. Muller The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection J. Leukoc. Biol., November 1, 2003; 74(5): 635 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Hatley, S. Srinivasan, K. B. Reilly, D. T. Bolick, and C. C. Hedrick Increased Production of 12/15 Lipoxygenase Eicosanoids Accelerates Monocyte/Endothelial Interactions in Diabetic db/db Mice J. Biol. Chem., July 3, 2003; 278(28): 25369 - 25375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Yachie, T. Toma, K. Mizuno, H. Okamoto, S. Shimura, K. Ohta, Y. Kasahara, and S. Koizumi Heme Oxygenase-1 Production by Peripheral Blood Monocytes During Acute Inflammatory Illnesses of Children Exp Biol Med, May 1, 2003; 228(5): 550 - 556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Litovsky, M. Madjid, A. Zarrabi, S. W. Casscells, J. T. Willerson, and M. Naghavi Superparamagnetic Iron Oxide-Based Method for Quantifying Recruitment of Monocytes to Mouse Atherosclerotic Lesions In Vivo: Enhancement by Tissue Necrosis Factor-{alpha}, Interleukin-1{beta}, and Interferon-{gamma} Circulation, March 25, 2003; 107(11): 1545 - 1549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Srinivasan, M. Yeh, E. C. Danziger, M. E. Hatley, A. E. Riggan, N. Leitinger, J. A. Berliner, and C. C. Hedrick Glucose Regulates Monocyte Adhesion Through Endothelial Production of Interleukin-8 Circ. Res., March 7, 2003; 92(4): 371 - 377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. V. Zerbinatti and R. W. Gore Uptake of modified low-density lipoproteins alters actin distribution and locomotor forces in macrophages Am J Physiol Cell Physiol, February 1, 2003; 284(2): C555 - C561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Huang, I. Ishii, W.-Y. Zhang, M. Sonobe, and H. S. Kruth PMA activation of macrophages alters macrophage metabolism of aggregated LDL J. Lipid Res., August 1, 2002; 43(8): 1275 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. K. Hansson Immune Mechanisms in Atherosclerosis Arterioscler Thromb Vasc Biol, December 1, 2001; 21(12): 1876 - 1890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. K. Hsiai, S. K. Cho, S. Reddy, S. Hama, M. Navab, L. L. Demer, H. M. Honda, and C. M. Ho Pulsatile Flow Regulates Monocyte Adhesion to Oxidized Lipid-Induced Endothelial Cells Arterioscler Thromb Vasc Biol, November 1, 2001; 21(11): 1770 - 1776. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Gerrity, R. Natarajan, J. L. Nadler, and T. Kimsey Diabetes-Induced Accelerated Atherosclerosis in Swine Diabetes, July 1, 2001; 50(7): 1654 - 1665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Kuhlencordt, J. Chen, F. Han, J. Astern, and P. L. Huang Genetic Deficiency of Inducible Nitric Oxide Synthase Reduces Atherosclerosis and Lowers Plasma Lipid Peroxides in Apolipoprotein E-Knockout Mice Circulation, June 26, 2001; 103(25): 3099 - 3104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Suzuki, M. Poot, R. G. Gerrity, and K. E. Bornfeldt Diabetes Accelerates Smooth Muscle Accumulation in Lesions of Atherosclerosis: Lack of Direct Growth-Promoting Effects of High Glucose Levels Diabetes, April 1, 2001; 50(4): 851 - 860. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Moatti, S. Faure, F. Fumeron, M. E. W. Amara, P. Seknadji, D. H. McDermott, P. Debre, M. C. Aumont, P. M. Murphy, D. de Prost, et al. Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease Blood, April 1, 2001; 97(7): 1925 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Stefanec Endothelial Apoptosis: Could It Have a Role in the Pathogenesis and Treatment of Disease? Chest, March 1, 2000; 117(3): 841 - 854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Schwartz The Intima : A New Soil Circ. Res., November 12, 1999; 85(10): 877 - 879. [Full Text] [PDF]
|
|
|
|
|
|
G. Walker, A. C. Langheinrich, E. Dennhauser, R. M. Bohle, T. Dreyer, J. Kreuzer, H. Tillmanns, R. C. Braun-Dullaeus, and W. Haberbosch 3-Deazaadenosine Prevents Adhesion Molecule Expression and Atherosclerotic Lesion Formation in the Aortas of C57BL/6J Mice Arterioscler Thromb Vasc Biol, November 1, 1999; 19(11): 2673 - 2679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Takaku, Y. Wada, K. Jinnouchi, M. Takeya, K. Takahashi, H. Usuda, M. Naito, H. Kurihara, Y. Yazaki, Y. Kumazawa, et al. An In Vitro Coculture Model of Transmigrant Monocytes and Foam Cell Formation Arterioscler Thromb Vasc Biol, October 1, 1999; 19(10): 2330 - 2339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hidaka, E. Hidaka, M. Tozuka, J. Nakayama, T. Katsuyama, and N. Fidge The identification of specific high density lipoprotein3 binding sites on human blood monocytes using fluorescence-labeled ligand J. Lipid Res., June 1, 1999; 40(6): 1131 - 1139. [Abstract] [Full Text]
|
|
|
|
|
|
G. J. Randolph, T. Luther, S. Albrecht, V. Magdolen, and W. A. Muller Role of Tissue Factor in Adhesion of Mononuclear Phagocytes to and Trafficking Through Endothelium In Vitro Blood, December 1, 1998; 92(11): 4167 - 4177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Nishimura, M. Harada-Shiba, S. Tajima, R. Sugano, T. Yamamura, Q. Z. Qiang, and A. Yamamoto Acquisition of Secretion of Transforming Growth Factor-beta 1 Leads to Autonomous Suppression of Scavenger Receptor Activity in a Monocyte-Macrophage Cell Line, THP-1 J. Biol. Chem., January 16, 1998; 273(3): 1562 - 1567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Brandl, T. Richter, K. Haug, M. G. Wilhelm, P. C. Maurer, and W. Nathrath Topographic Analysis of Proliferative Activity in Carotid Endarterectomy Specimens by Immunocytochemical Detection of the Cell Cycle–Related Antigen Ki-67 Circulation, November 18, 1997; 96(10): 3360 - 3368. [Abstract] [Full Text]
|
|
|
|
|
|
S. Miura, T. Chiba, N. Mochizuki, H. Nagura, K. Nemoto, I. Tomita, M. Ikeda, and T. Tomita Cholesterol-Mediated Changes of Neutral Cholesterol Esterase Activity in Macrophages : Mechanism for Mobilization of Cholesteryl Esters in Lipid Droplets by HDL Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 3033 - 3040. [Abstract] [Full Text]
|
|
|
|
|
|
W. G. Jerome and J. C. Lewis Cellular Dynamics in Early Atherosclerotic Lesion Progression in White Carneau Pigeons : Spatial and Temporal Analysis of Monocyte and Smooth Muscle Invasion of the Intima Arterioscler Thromb Vasc Biol, April 1, 1997; 17(4): 654 - 664. [Abstract] [Full Text]
|
|
|
|
|
|
R. C. Candipan, B.-y. Wang, R. Buitrago, P. S. Tsao, and J. P. Cooke Regression or Progression : Dependency on Vascular Nitric Oxide Arterioscler Thromb Vasc Biol, January 1, 1996; 16(1): 44 - 50. [Abstract] [Full Text]
|
|
|
|
|
|
M. Takahashi, J.-I. Masuyama, U. Ikeda, S.-I. Kitagawa, T. Kasahara, M. Saito, S. Kano, and K. Shimada Suppressive Role of Endogenous Endothelial Monocyte Chemoattractant Protein–1 on Monocyte Transendothelial Migration In Vitro Arterioscler Thromb Vasc Biol, May 1, 1995; 15(5): 629 - 636. [Abstract] [Full Text]
|
|
|
|
|
|
M. Takahashi, J.-I. Masuyama, U. Ikeda, T. Kasahara, S.-I. Kitagawa, Y.-I. Takahashi, K. Shimada, and S. Kano Induction of Monocyte Chemoattractant Protein-1 Synthesis in Human Monocytes During Transendothelial Migration In Vitro Circ. Res., May 1, 1995; 76(5): 750 - 757. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. Berliner, M. Navab, A. M. Fogelman, J. S. Frank, L. L. Demer, P. A. Edwards, A. D. Watson, and A. J. Lusis Atherosclerosis: Basic Mechanisms : Oxidation, Inflammation, and Genetics Circulation, May 1, 1995; 91(9): 2488 - 2496. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Lynch and B. Frei Reduction of Copper, but Not Iron, by Human Low Density Lipoprotein (LDL) J. Biol. Chem., March 10, 1995; 270(10): 5158 - 5163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Proudfoot, D. Parrott, and D. Bowyer A dialysis culture system for the study of the production and modulation of growth-regulatory molecules: studies using the P388D1 macrophage cell line J. Cell Sci., January 1, 1995; 108(1): 379 - 386. [Abstract] [PDF]
|
|
|
|
|
|
H. McMurray, D Proudfoot, J. Davis, D. Parrott, and D. Bowyer A small molecular mass inhibitor of growth of 3T3 cells and porcine aortic smooth muscle cells released from the macrophage cell line P388D1 J. Cell Sci., January 12, 1993; 106(4): 1301 - 1311. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Steinberg, T. A. Pearson, and L. H. Kuller Alcohol and Atherosclerosis Ann Intern Med, June 1, 1991; 114(11): 967 - 976. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Steinberg and J. L. Witztum Lipoproteins and Atherogenesis: Current Concepts JAMA, December 19, 1990; 264(23): 3047 - 3052. [Abstract] [PDF]
|
|
|
|
 |
|
 R Ross, J Masuda, E. Raines, A. Gown, S Katsuda, M Sasahara, L. Malden, H Masuko, and H Sato Localization of PDGF-B protein in macrophages in all phases of atherogenesis Science, May 25, 1990; 248(4958): 1009 - 1012. [Abstract] [PDF]
|
|
|
|
|
|
P. M. Yao and I. Tabas Free Cholesterol Loading of Macrophages Induces Apoptosis Involving the Fas Pathway J. Biol. Chem., July 28, 2000; 275(31): 23807 - 23813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-Y. Zhang, I. Ishii, and H. S. Kruth Plasmin-mediated Macrophage Reversal of Low Density Lipoprotein Aggregation J. Biol. Chem., October 13, 2000; 275(42): 33176 - 33183. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
