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American Journal of Pathology, Vol 104, 98-102, Copyright © 1981 by American Society for Investigative Pathology

REGULAR ARTICLES

Irreversible neutrophil aggregation. A mechanism of decreased newborn neutrophil chemotactic response

AD Mease, DP Burgess and PJ Thomas

To investigate the neutrophil-neutrophil interactions of the newborn for possible clues to the etiology of decreased newborn neutrophil (PMN) chemotaxis, the authors compared adult and newborn C5a-induced PMN aggregation and chemotaxis at various PMN concentrations. Using Craddock's technique of C5a-induced aggregation, the authors found that the newborn lacks the normal biphasic aggregation-deaggregation seen in the adult, suggesting irreversible aggregation similar to that seen when adult PMNs are pretreated with cytochalasin-B. Chemotaxis of adult and newborn PMNs was studied with a modified Gallin radiolabel technique. A linear correlation between PMN concentration and corrected chemotactic response was found with both adult (r2 = 0.93) and newborn (r2 = 0.90) PMNs in the range 0.1 X 10(6) to 20 X 10(6) PMNs/ml. Random migration was not augmented by increased PMN concentration. The augmentation of newborn PMN chemotaxis was less than that of the adult (adult slope = 2426; newborn slope = 983). Irreversible newborn PMN aggregation may be the underlying event producing decreased PMN chemotaxis and interfering with the normal chemotactic augmentation caused by increased PMN concentration.


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 J Intensive Care MedHome page
T. E. Harper and R. D. Christensen
Bacterial Sepsis in the Newborn Infant: Developmental Deficiencies in Neutrophils and the Role of Neutrophil Transfusion
J Intensive Care Med, September 1, 1987; 2(5): 279 - 291.
[Abstract] [PDF]


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Copyright © 1981 by the American Society for Investigative Pathology.