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American Journal of Pathology, Vol 104, 250-257, Copyright © 1981 by American Society for Investigative Pathology

REGULAR ARTICLES

The ultrastructure of spontaneous coronary arterial lesions in steelhead trout (Salmo gairdneri)

EW House and EP Benditt

Electron-microscopic examination of spontaneously occurring coronary arterial lesions in adult spawning steelhead trout showed them to be subendothelial accumulations of modified smooth muscle cells covered by an intact endothelium. Some of the cells in the nodules appeared highly vacuolated and seemed to be associated with varying amounts of collagen and elastin. The internal elastic lamina was often doubled with smooth muscle cells between the layers. The thickness of the internal elastica was altered and, in some lesions, penetrated by smooth muscle cells. In the smallest lesions, smooth muscle cells appeared to be penetrating the internal elastic lamina and were usually close to a highly vacuolated intimal endothelial cell. The underlying medial layer frequently exhibited altered orientation of the cells, with the frequent appearance of increased collagen and amorphous extracellular material. No lipid was present in any lesion. Although vacuolation of endothelial cells suggested some alteration in endothelial cells, at least in developed lesions, no evidence of endothelial denudation over lesions was observed.


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L. B. CHRISTIANSEN, T. MUSTAFA, and B. KORSGAARD
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Copyright © 1981 by the American Society for Investigative Pathology.