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American Journal of Pathology, Vol 105, 97-106, Copyright © 1981 by American Society for Investigative Pathology

REGULAR ARTICLES

Comparison of histologic and immunologic heterogeneity of non-Hodgkin's lymphomas

MJ Borowitz, BP Croker and RS Metzgar

The lymphocyte surface marker phenotype in 11 selected cases of non- Hodgkin's lymphomas was determined with anti-immunoglobulin and mouse monoclonal antibodies against human lymphocyte antigens. A complement- mediated cell cytotoxicity assay on suspensions of the tumor cells was compared with an indirect immunoperoxidase technique on frozen tissue sections. Both methods gave good results in tumors with a uniform cell population, but the frozen section technique was superior in heterogeneous tumors. The six B-cell neoplasms were heterogeneous with respect to expression of surface immunoglobulin and Ia antigens. The five T-cell tumors were morphologically heterogeneous and also highly variable in their expression of different T-cell specific antigens.




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Copyright © 1981 by the American Society for Investigative Pathology.