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American Journal of Pathology, Vol 105, 255-263, Copyright © 1981 by American Society for Investigative Pathology

REGULAR ARTICLES

Glycogen accumulation in alveolar type II cells in 3-methylindole-- induced pulmonary edema in goats

OS Atwal and TM Bray

The present study shows that intravenous infusion of 3-methylindole (3MI) induced acute pulmonary edema in goats. Edematous changes were seen in the alveoli and the interalveolar interstitium. At 72 hours after treatment, an accumulation of glycogen that had a pathognomonic appearance of alpha particles was observed in the alveolar Type II cells. A rich accumulation of glycogen particles and defective lamellar bodies containing triglycerides were the significant morphologic changes in the alveolar Type II cells. These findings suggest that massive glycogen deposition in the alveolar Type II cells is a defect that might interfere with surfactant production, further complicating the disease process.




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Copyright © 1981 by the American Society for Investigative Pathology.