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American Journal of Pathology, Vol 105, 306-315, Copyright © 1981 by American Society for Investigative Pathology

REGULAR ARTICLES

BCL1, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure

MJ Muirhead, JM Holbert Jr, JW Uhr and ES Vitetta

The transplantable murine B-cell leukemia, BCL1, was examined by light and electron microscopy. The results show that the BCL1 cell closely resembles the prolymphocyte of human prolymphocytic leukemia (PLL). The spleen of animals transplanted with BCL1 is diffusely infiltrated by BCL1-prolymphocytes. Splenectomized animals given transplants of BCL1 develop a lymphomalike disease with less leukemia and bone marrow involvement than the nonsplenectomized transplant recipients. Ultrastructural features of the BCL1 cell are identical in the splenectomized and nonsplenectomized animals.


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E. Vitetta, K. Krolick, M Miyama-Inaba, W Cushley, and J. Uhr
Immunotoxins: a new approach to cancer therapy
Science, February 11, 1983; 219(4585): 644 - 650.
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Copyright © 1981 by the American Society for Investigative Pathology.