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American Journal of Pathology, Vol 106, 165-170, Copyright © 1982 by American Society for Investigative Pathology

REGULAR ARTICLES

Epithelioid granuloma formation requiring no T-cell function

A Tanaka, K Emori, S Nagao, k Kushima, O Kohashi, M Saitoh and T Kataoka

Muramyl dipeptide (MDP), a minimal structure in bacterial cell walls essential for their adjuvant activity, was incorporated in a water-in- oil emulsion and injected into the footpads of nude rats devoid of functional T cells. MDP thus injected evoked massive epithelioid granulomas in the draining lymph nodes, indicating that MDP induced epithelioid granuloma formation requires no T cells. This finding with other data available strongly suggest that epithelioid granulomas can be induced without immunologic reactions.




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Copyright © 1982 by the American Society for Investigative Pathology.