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American Journal of Pathology, Vol 106, 187-203, Copyright © 1982 by American Society for Investigative Pathology

REGULAR ARTICLES

Human T-cell malignancies: Correlative clinical, histopathologic, immunologic, and cytochemical analysis of 23 cases

DM Knowles 2d and JP Halper

Twenty-three T-cell neoplasms were investigated for their reactivity with the OKT monoclonal antibodies and expression of certain cytochemical markers. Fourteen neoplasms with diverse histopathologic features, T-cell chronic lymphocytic leukemia, mycosis fungoides, the Sezary syndrome, T-immunoblastic sarcoma, and a pleomorphic large-cell lymphoma, expressed the T helper cell phenotype, OKT3+T4+. Nine other neoplasms displayed marked inter- and intra- tumor heterogeneity. Seven of these cases, lymphoblastic lymphoma, T-cell acute lymphoblastic leukemia, and tumors with feature of T-immunoblastic sarcoma or the multilobated lymphoma of Pinkus, expressed intrathymic phenotypes. The other 2 cases, a lymphoblastic lymphoma and a so-called Lennert's lymphoma, expressed the previously undescribed OKT3+T10+ phenotype. These studies demonstrate that the T-cell malignancies are divisible into phenotypes corresponding to normal maturational stages of T-cell differentiation and functionally distinct T-cell subsets. Such studies should provide a basis for understanding the biologic heterogeneity, clinical diversity, and significance of the variable cytomorphologic characteristics of T-cell malignant tumors and assist in the further delineation of normal human T-cell heterogeneity.


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D. Tse, M Al-Haideri, B Pernis, C. Cantor, and C. Wang
Intracellular accumulation of T-cell receptor complex molecules in a human T-cell line
Science, November 7, 1986; 234(4777): 748 - 751.
[Abstract] [PDF]


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Copyright © 1982 by the American Society for Investigative Pathology.