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American Journal of Pathology, Vol 106, 224-236, Copyright © 1982 by American Society for Investigative Pathology

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Dwarfism in Alaskan malamutes: a disease resembling metaphyseal dysplasia in human beings

RD Sande, JE Alexander, GR Spencer, GA Padgett and WC Davis

In a study of 300 Alaskan Malamutes, dwarfism was shown to be an autosomal recessive inherited disease with complete penetrance that resulted in disturbed endochondral bone formation. Osseous growth disturbance was manifest at the metaphyses of tubular bones. Clinical and radiographic changes were very similar to those of rickets, although appositional bone formation rates were normal. Serum calcium, phosphorus, and alkaline phosphatase were within normal limits. Urinary excretion of calcium, phosphate, and amino acids were normal. Excess matrix was formed in the zone of cartilage cell proliferation, and the matrix persisted in the growth plate. Normal stresses resulted in microfractures in the metaphyses with subsequent interference of vascular penetration into the zone of degenerated cartilage cells.




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Copyright © 1982 by the American Society for Investigative Pathology.