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American Journal of Pathology, Vol 107, 357-361, Copyright © 1982 by American Society for Investigative Pathology

REGULAR ARTICLES

Use of monoclonal antibodies in detection of melanoma-associated antigens in intact human tumors

JJ Thompson, MF Herlyn, DE Elder, WH Clark, Z Steplewski and H Koprowski

The use of antimelanoma monoclonal antibodies on tissue sections using a two-step indirect immunoperoxidase technique is reported. Antibodies 691-13-17 and 691-I5-Nu4B reacted with dysplastic nevus cells and all melanomas tested, but not with normal skin melanocytes, intradermal nevi, or lentigines. Antibody 691-13-17, directed against DR antigen, reacted also with Langerhan's cells, macrophages, and a subpopulation of lymphocytes. Antibody 691-I5-Nu4B reacted only with melanomas. The technique allows analysis of the expression of antigens by tumor cells in situ.




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Copyright © 1982 by the American Society for Investigative Pathology.