help button home button Am J Pathol JNCI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harris, N. L.
Right arrow Articles by Dvorak, H. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harris, N. L.
Right arrow Articles by Dvorak, H. F.

American Journal of Pathology, Vol 108, 119-129, Copyright © 1982 by American Society for Investigative Pathology

REGULAR ARTICLES

Fibrin deposits in Hodgkin's disease

NL Harris, AM Dvorak, J Smith and HF Dvorak

Fibrin deposits were observed in the involved lymph nodes and/or spleens of 15 patients with Hodgkin's disease by specific immunofluorescence and by electron microscopy. Two basic patterns of fibrin deposition were observed: 1) intercellular deposits, chiefly associated with nonneoplastic-appearing lymphoid cells and 2) deposits associated with the collagen fibers of young connective tissue. In addition, coarse fibrin deposits were observed in areas of necrosis, presumably a non-specific finding. Fibronectin was also observed in intercellular areas, but staining was less intense than for fibrin. Fibrin deposits were also observed in 3 of 6 cases of non-Hodgkin's lymphoma, indicating that the finding is not an exclusive feature of Hodgkin's disease. The pathogenesis and possible significance of fibrin deposition in Hodgkin's disease are related to earlier observations of activation of the coagulation system on neoplasia and cell-mediated immunity and to the possible role of fibrin, fibronectin, and their breakdown products in angiogenesis and fibroplasia.


This article has been cited by other articles:


Home page
 BloodHome page
J. S. Palumbo, K. W. Kombrinck, A. F. Drew, T. S. Grimes, J. H. Kiser, J. L. Degen, and T. H. Bugge
Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells
Blood, November 15, 2000; 96(10): 3302 - 3309.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
M. Hejna, M. Raderer, and C. C. Zielinski
Inhibition of Metastases by Anticoagulants
J Natl Cancer Inst, January 6, 1999; 91(1): 22 - 36.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. H. Bugge, K. W. Kombrinck, Q. Xiao, K. Holmback, C. C. Daugherty, D. P. Witte, and J. L. Degen
Growth and Dissemination of Lewis Lung Carcinoma in Plasminogen-Deficient Mice
Blood, December 1, 1997; 90(11): 4522 - 4531.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1982 by the American Society for Investigative Pathology.