help button home button Am J Pathol R & D Systems
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cornwell, G. G.
Right arrow Articles by Pitkanen, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cornwell, G. G., 3d
Right arrow Articles by Pitkanen, P.

American Journal of Pathology, Vol 108, 135-139, Copyright © 1982 by American Society for Investigative Pathology

REGULAR ARTICLES

Senile aortic amyloid. A third distinctive type of age-related cardiovascular amyloid

GG Cornwell 3d, P Westermark, W Murdoch and P Pitkanen
Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755.

Aortic tissues from 22 elderly patients were analyzed by Congo red staining for amyloid deposits. All samples contained amyloid, which was resistant to the potassium permanganate reaction. Tryptophan was present in all amyloid deposits. The amyloid failed to react with antiserums to amyloid fibril protein ASc1 or human prealbumin, proteins previous demonstrated in generalized senile cardiac amyloid. It also differed from age-related isolated atrial amyloid, which has been shown to lack tryptophan. Deposits did not react with antiserums specific for amyloid fibril proteins of the A lambda IV, A lambda VI, AA, or AEt types. These results indicate that senile aortic amyloid is distinct from amyloid present in primary and secondary amyloidosis and appears to represent a third form of cardiovascular amyloid associated with the aging process.


This article has been cited by other articles:


Home page
 J. Clin. Pathol.Home page
I Kholova and H W M Niessen
Amyloid in the cardiovascular system: a review
J. Clin. Pathol., February 1, 2005; 58(2): 125 - 133.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
H. T. Blumenthal
Amyloidosis: A Universal Disease of Aging?
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2004; 59(4): M361 - M369.
[Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
H. T. Blumenthal
Guest Editorial: The Autopsy in Gerontological Research: A Retrospective
J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2002; 57(7): M433 - 437.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1982 by the American Society for Investigative Pathology.