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American Journal of Pathology, Vol 109, 97-106, Copyright © 1982 by American Society for Investigative Pathology

REGULAR ARTICLES

The role of complement in the induction of acute antibody-mediated vasculitis of rat skin grafts in the mouse

MJ Bogman, JH Berden, IM Cornelissen, CN Maass and RA Koene

Rat skin grafts carried by immunosuppressed mice can be acutely destroyed by intravenous administration of mouse anti-rat antibody. The velocity of the reaction and the histologic sequence of events depend on the amount of antibody administered: low doses give an Arthus-like rejection, whereas at high doses a Shwartzman-like pattern occurs. Depletion of C3 by cobra venom factor treatment did not prevent acute rejection after intravenous injection of high doses of antiserum but changed the reaction from a Shwartzman-like to an Arthus-like pattern. Conversely, supplementary administration of rabbit complement caused a violent Shwartzman-like graft destruction after injection of low doses of antibody, which in complement-normal mice gave an Arthus-like reaction. The results show that complement can greatly amplify the antibody-mediated immune vasculitis and can substantially modify its histologic pattern. It is, however, not an absolute requirement for the occurrence of the destructive process.




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Copyright © 1982 by the American Society for Investigative Pathology.