help button home button Am J Pathol ASIP 2008 Summer Academy, Molecular Methcanisms of Human Disease: Injury, Inflammation, and Tissue Repair
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gerber, M. A.
Right arrow Articles by Ishak, K. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gerber, M. A.
Right arrow Articles by Ishak, K. G.

American Journal of Pathology, Vol 110, 70-74, Copyright © 1983 by American Society for Investigative Pathology

REGULAR ARTICLES

Phenotypic characterization of hepatic proliferation. Antigenic expression by proliferating epithelial cells in fetal liver, massive hepatic necrosis, and nodular transformation of the liver

MA Gerber, SN Thung, S Shen, FW Stromeyer and KG Ishak

Different forms of hepatocellular proliferation are seen in fetal livers, massive hepatic necrosis, and nodular transformation (nodular regenerative hyperplasia) of the liver. In an attempt to characterize the proliferating cells in these conditions, we studied the expression of several antigens by immunohistochemical methods. Alpha-fetoprotein (AFP), alpha 1-antitrypsin (AAT), a hepatocellular export protein, carcinoembryonic antigen (CEA), a marker of bile duct epithelial cells, and hepatitis B virus antigens (HBsAg, HBcAg), were localized by the peroxidase-antiperoxidase method in 11 fetal livers, 10 cases of nodular transformation, and 7 cases of massive hepatic necrosis. AFP was the most prevalent antigen in fetal hepatocytes. Many hyperplastic hepatocytes in nodular transformation contained AAT, but not oncofetal antigens, supporting the differentiated hepatocellular nature of these cells. A similar staining pattern was seen in two-cell-thick plates of hepatocytes in massive hepatic necrosis. In contrast, the ductlike structures at the periphery of necrotic lobules contained both AAT and CEA, suggesting that these cells exhibit features of hepatocytes and bile duct epithelial cells. Therefore, the appropriate term for these regenerating cells appears to be "ductular" or "biliary hepatocytes".


This article has been cited by other articles:


Home page
 JCOHome page
S. Sell and H. L. Leffert
Liver Cancer Stem Cells
J. Clin. Oncol., June 10, 2008; 26(17): 2800 - 2805.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
R. A. Davies, B. Knight, Y. W. Tian, G. C.T. Yeoh, and J. K. Olynyk
Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor
Carcinogenesis, August 1, 2006; 27(8): 1607 - 1616.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
B. Knight, G. C.T. Yeoh, K. L. Husk, T. Ly, L. J. Abraham, C. Yu, J. A. Rhim, and N. Fausto
Impaired Preneoplastic Changes and Liver Tumor Formation in Tumor Necrosis Factor Receptor Type 1 Knockout Mice
J. Exp. Med., December 18, 2000; 192(12): 1809 - 1818.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. Fabris, M. Strazzabosco, H. A. Crosby, G. Ballardini, S. G. Hubscher, D. A. Kelly, J. M. Neuberger, A. J. Strain, and R. Joplin
Characterization and Isolation of Ductular Cells Coexpressing Neural Cell Adhesion Molecule and Bcl-2 from Primary Cholangiopathies and Ductal Plate Malformations
Am. J. Pathol., May 1, 2000; 156(5): 1599 - 1612.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1983 by the American Society for Investigative Pathology.