This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Foidart, J. M. Articles by Liotta, L. A. Search for Related Content PubMed PubMed Citation Articles by Foidart, J. M. Articles by Liotta, L. A.

American Journal of Pathology, Vol 110, 346-357, Copyright © 1983 by American Society for Investigative Pathology

REGULAR ARTICLES

Abortion in mice induced by intravenous injections of antibodies to type IV collagen or laminin

JM Foidart, M Yaar, A Figueroa, A Wilk, KS Brown and LA Liotta

Purified antibodies to laminin or Type IV collagen administered intravenously to pregnant mice were found to localize in the basement membranes of all maternal tissues as well as the parietal and visceral yolk sacs and trophoblast basement membranes but not in embryonic tissues. Antibodies to Type IV collagen induced a higher incidence of abortions, retroplacental hematomas and fetal deaths. When administered intraamniotically, both antiserums were embryotoxic. The functional consequences of the attachment of antibodies to these specific basement membrane antigens appear to be hemorrhage within the parietal and visceral yolk sacs and separation of fetal from maternal tissues. Complement activation appears to play an important role in the interruptions of pregnancy, because this was not observed in strains of mice lacking C5, the fifth component of complement, in mice depleted of C3 by administration of cobra venom factor, or in mice injected with the F(ab) fragments of antibody to Type IV collagen or laminin.

This article has been cited by other articles:

				J. INAGAKI, A. KONDO, L. R. LOPEZ, Y. SHOENFELD, and E. MATSUURA Pregnancy Loss and Endometriosis: Pathogenic Role of Anti-Laminin-1 Autoantibodies Ann. N.Y. Acad. Sci., June 1, 2005; 1051(1): 174 - 184. [Abstract] [Full Text] [PDF]

				Y Shoenfeld and M Blank Autoantibodies associated with reproductive failure Lupus, September 1, 2004; 13(9): 643 - 648. [Abstract] [PDF]

				J. Inagaki, M. Sugiura-Ogasawara, M. Nomizu, M. Nakatsuka, K. Ikuta, N. Suzuki, K. Kaihara, K. Kobayashi, T. Yasuda, Y. Shoenfeld, et al. An association of IgG anti-laminin-1 autoantibodies with endometriosis in infertile patients Hum. Reprod., March 1, 2003; 18(3): 544 - 549. [Abstract] [Full Text] [PDF]

				M. G. Kolonin, R. Pasqualini, and W. Arap Teratogenicity induced by targeting a placental immunoglobulin transporter PNAS, October 1, 2002; 99(20): 13055 - 13060. [Abstract] [Full Text] [PDF]