This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Millard, P. R. Articles by Morris, P. J. Search for Related Content PubMed PubMed Citation Articles by Millard, P. R. Articles by Morris, P. J.

American Journal of Pathology, Vol 111, 166-173, Copyright © 1983 by American Society for Investigative Pathology

REGULAR ARTICLES

The long-term allografted rat islet. A histologic and immunohistologic study

PR Millard, H Reece-Smith, A Clark, EL Jeffery, P McShane and PJ Morris

Long-term survival of islet allografts was achieved with an experimental model in the rat by the transplantation of islet/kidney composite grafts. Morphologic studies of these grafts incorporating immunocytochemistry have been made. Ther was minimal evidence of rejection of the transplanted islet tissue, which was composed almost entirely of insulin-containing cells. There were a few glucagon- containing cells, but pancreatic polypeptide-labeled and somatostatin- labeled cells were rarely seen. The endocrine cells were in different proportions and had no discernible relationship to one another, in contrast to those in nontransplanted islets. For successful clinical transplantation, it may be necessary to maintain normal relationships between endocrine cells.