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American Journal of Pathology, Vol 113, 309-314, Copyright © 1983 by American Society for Investigative Pathology

REGULAR ARTICLES

The rapid induction of liver cell death in rats fed a choline-deficient methionine-low diet

AK Ghoshal, M Ahluwalia and E Farber

This study was undertaken to test the hypothesis that the basis for the cell proliferation seen in the livers of rats fed a choline-deficient methionine-low (CMD) diet is regeneration following hepatocyte cell death and necrosis. Exposure of rats to a CMD diet for 2 weeks was found to induce liver cell loss and necrosis as monitored by three different approaches: 1) histologic examination, 2) serum sorbitol dehydrogenase assay, and 3) measurement of the total radioactivity in liver DNA prelabeled during a prior period of regeneration. These observations suggest that the basis for liver cell proliferation in rats fed a CMD diet probably resides in the cell loss and necrosis induced in the liver by the deficient diet.


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Copyright © 1983 by the American Society for Investigative Pathology.