This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sell, S. Articles by Salman, J. Search for Related Content PubMed PubMed Citation Articles by Sell, S. Articles by Salman, J.

American Journal of Pathology, Vol 114, 287-300, Copyright © 1984 by American Society for Investigative Pathology

REGULAR ARTICLES

Light- and electron-microscopic autoradiographic analysis of proliferating cells during the early stages of chemical hepatocarcinogenesis in the rat induced by feeding N-2- fluorenylacetamide in a choline-deficient diet

S Sell and J Salman

Proliferating cells that appear after feeding the hepatocarcinogen N-2- fluorenylacetamide in a choline-deficient diet were identified by autoradiographic electron and light microscopy. Labeled cells are first seen as nondescript periductular cells 1 day after feeding carcinogen. Proliferation of duct lining cells begins at 2-3 days. For the next three weeks there is proliferation and extension of a mixture of nondescript cells and cells with a duct like appearance from the portal zone into the adjacent liver. By 3-4 weeks the entire liver lobule contains this new cell population. At 3 weeks more differentiated duct like structures are seen at the edge of the advancing new cell population. Newly appearing duct like cells differ from normal duct cells in that they contain AFP and albumin. It is concluded that the new cell population may arise from duct cells or periportal "stem" cells, or both.

This article has been cited by other articles:

				D. R. Crawford, S. Ostrowski, D. Vakharia, Z. Ilic, and S. Sell Separate Origins of Hepatitis B Virus Surface Antigen-Negative Foci and Hepatocellular Carcinomas in Transgenic HBsAg (alb/psx) Mice Am. J. Pathol., July 1, 2006; 169(1): 223 - 232. [Abstract] [Full Text] [PDF]

				K. M. Braun, A. W. Thompson, and E. P. Sandgren Hepatic Microenvironment Affects Oval Cell Localization in Albumin-Urokinase-Type Plasminogen Activator Transgenic Mice Am. J. Pathol., January 1, 2003; 162(1): 195 - 202. [Abstract] [Full Text] [PDF]

				E. J. Croager, P. G.J. Smith, and G. C.T. Yeoh Ethanol interactions with a choline-deficient, ethionine-supplemented feeding regime potentiate pre-neoplastic cellular alterations in rat liver Carcinogenesis, October 1, 2002; 23(10): 1685 - 1694. [Abstract] [Full Text] [PDF]

				S. Paku, J. Schnur, P. Nagy, and S. S. Thorgeirsson Origin and Structural Evolution of the Early Proliferating Oval Cells in Rat Liver Am. J. Pathol., April 1, 2001; 158(4): 1313 - 1323. [Abstract] [Full Text] [PDF]

				K. M. Braun and E. P. Sandgren Cellular Origin of Regenerating Parenchyma in a Mouse Model of Severe Hepatic Injury Am. J. Pathol., August 1, 2000; 157(2): 561 - 569. [Abstract] [Full Text] [PDF]

				P. M. Novikoff and A. Yam Stem Cells and Rat Liver Carcinogenesis: Contributions of Confocal and Electron Microscopy J. Histochem. Cytochem., May 1, 1998; 46(5): 613 - 626. [Abstract] [Full Text]

				S. Sell Electron Microscopic Identification of Putative Liver Stem Cells and Intermediate Hepatocytes following Periportal Necrosis Induced in Rats by Allyl Alcohol Stem Cells, September 1, 1997; 15(5): 378 - 385. [Abstract] [Full Text]