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American Journal of Pathology, Vol 115, 25-30, Copyright © 1984 by American Society for Investigative Pathology

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Experimental pyelonephritis. The effect of T-cell deficiency on the course of hematogenous enterococcal pyelonephritis in the mouse

H Pitchon, R Glassock, GM Kalmanson and LB Guze

The course of experimental hematogenous pyelonephritis due to Streptococcus faecalis was compared in athymic (nu/nu) mice and euthymic (nu/+) littermates. Up to 7 weeks following infection, there were no significant differences in renal microbial populations. At 63 and 107-131 days there was significant escalation of infection in nu/nu mice, while the nu/+ mice were decreasing their infections. There was no increase in gross abscess formation in nu/nu mice, but in late stages significantly more gross scarring occurred in nu/nu as compared with nu/+ mice. Microscopically there was also greater scarring in nu/nu mice late in the disease, except for calyceal lesions. The data suggest that immunologic factors (T cells) are involved in the pathogenesis of chronic pyelonephritis.