This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nachtigal, M. Articles by Caulfield, J. B. Search for Related Content PubMed PubMed Citation Articles by Nachtigal, M. Articles by Caulfield, J. B.

American Journal of Pathology, Vol 115, 175-185, Copyright © 1984 by American Society for Investigative Pathology

REGULAR ARTICLES

Early and late pathologic changes in the adrenal glands of mice after infection with herpes simplex virus type 1

M Nachtigal and JB Caulfield

Intranasal infection of CH/HeN mice with herpes simplex virus Type 1 (HSV-1), VR3 strain, caused a high death rate in the 3-12 days following inoculation. Acute interstitial pneumonia and focal adrenal necrosis developed in almost all the animals. About 20% of the mice showed meningoencephalitis and myocarditis. Viral antigen was demonstrated by immunoperoxidase staining in the alveolar walls, around bronchi and blood vessels, and in focal areas of the adrenal cortex as early as 24-48 hours after infection. The virus disseminated probably hematogenously from the lungs and seemed to localize preferentially in the adrenals. In mice surviving the acute stage of infection a subcapsular cell reaction developed in the adrenal cortex. The extensive pneumonia and adrenal necrosis contributed to the high mortality rate of weanling mice infected with HSV-1. The route of viral inoculation and the age of the host animal seemed to influence the localization and outcome of the pathologic process.

This article has been cited by other articles:

				E. A. Murphy, J. M. Davis, A. S. Brown, M. D. Carmichael, J. A. Carson, N. Van Rooijen, A. Ghaffar, and E. P. Mayer Benefits of oat {beta}-glucan on respiratory infection following exercise stress: role of lung macrophages Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1593 - R1599. [Abstract] [Full Text] [PDF]

				A. S. Brown, J. M. Davis, E. A. Murphy, M. D. Carmichael, J. A. Carson, A. Ghaffar, and E. P. Mayer Susceptibility to HSV-1 infection and exercise stress in female mice: role of estrogen J Appl Physiol, November 1, 2007; 103(5): 1592 - 1597. [Abstract] [Full Text] [PDF]

				J. S. Burgos, C. Ramirez, I. Sastre, J. M. Alfaro, and F. Valdivieso Herpes Simplex Virus Type 1 Infection via the Bloodstream with Apolipoprotein E Dependence in the Gonads Is Influenced by Gender J. Virol., February 1, 2005; 79(3): 1605 - 1612. [Abstract] [Full Text] [PDF]

				E. A. Murphy, J. M. Davis, A. S. Brown, M. D. Carmichael, N. Van Rooijen, A. Ghaffar, and E. P. Mayer Role of lung macrophages on susceptibility to respiratory infection following short-term moderate exercise training Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1354 - R1358. [Abstract] [Full Text] [PDF]

				L. Barzon, M. Boscaro, and G. Palu Endocrine Aspects of Cancer Gene Therapy Endocr. Rev., February 1, 2004; 25(1): 1 - 44. [Abstract] [Full Text] [PDF]

				J. M. Davis, E. A. Murphy, A. S. Brown, M. D. Carmichael, A. Ghaffar, and E. P. Mayer Effects of moderate exercise and oat {beta}-glucan on innate immune function and susceptibility to respiratory infection Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2004; 286(2): R366 - R372. [Abstract] [Full Text] [PDF]

				J. M. Davis, M. L. Kohut, L. H. Colbert, D. A. Jackson, A. Ghaffar, and E. P. Mayer Exercise, alveolar macrophage function, and susceptibility to respiratory infection J Appl Physiol, November 1, 1997; 83(5): 1461 - 1466. [Abstract] [Full Text] [PDF]