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American Journal of Pathology, Vol 116, 107-114, Copyright © 1984 by American Society for Investigative Pathology

REGULAR ARTICLES

Differences in the occurrence of hypertension among (NZB X NZW)F1, MRL- lpr, and BXSB mice with lupus nephritis

UH Rudofsky, RL Dilwith, JB Roths, DA Lawrence, VE Kelley and AM Magro

Lupus-prone (NZB X NZW)F1 (B X W) mice and MRL-lpr and BXSB mice were examined for the prevalence of hypertension and levels of plasma renin activity (PRA). Hypertension (greater than 145 mmHg) was observed only in female and male B X W mice with severe nephritis; in female MRL-lpr and male BXSB mice severe nephritis developed without blood pressure elevation (80-135 mmHg). The B X W parental strains, NZB and NZW, and the MRL-lpr congenic partners, MRL- +, did not become hypertensive as they aged. Other strains of mice, aged 3-32 months (A/HeN, BALB/cJ, BALB/cByJ, B10.S/Sg, B10.D2/ oSn , CBA/J, C3H/HeJ, SJL/J and [SJL X NZW]F1), also had normal blood pressure (98-122 mmHg). All mice with lupus nephritis had low PRA, even those with hypertension; furthermore, the MRL-lpr strain had low or undetectable PRA (2 +/- 1 ng/ml/hr), even when kidneys were normal. NZB, NZW, and MRL- + mice had normal PRA (10- 16 ng/ml/hr). Thus, B X W mice frequently developed low renin hypertension during the last phase of their renal disease; whereas MRL- lpr and BXSB mice died from renal disease without observable increases in blood pressure.


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M. J. Ryan and G. R. McLemore Jr.
Hypertension and impaired vascular function in a female mouse model of systemic lupus erythematosus
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R736 - R742.
[Abstract] [Full Text] [PDF]


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Copyright © 1984 by the American Society for Investigative Pathology.