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American Journal of Pathology, Vol 117, 30-36, Copyright © 1984 by American Society for Investigative Pathology

REGULAR ARTICLES

Quantitative indexes of aminonucleoside-induced nephrotic syndrome

TE Nevins, T Gaston and JM Basgen

Aminonucleoside of puromycin (PAN) is known to cause altered glomerular permeability, resulting in a nephrotic syndrome in rats. The early sequence of this lesion was studied quantitatively, with the application of a new morphometric technique for determining epithelial foot process widths and a sensitive assay for quantifying urinary albumin excretion. Twenty-four hours following a single intraperitoneal injection of PAN, significant widening of foot processes was documented. Within 36 hours significant increases in urinary albumin excretion were observed. When control rats were examined, there was no clear correlation between epithelial foot process width and quantitative albumin excretion. However, in the PAN-treated animals, abnormal albuminuria only appeared in association with appreciable foot process expansion. These studies indicate that quantitative alterations occur in the rat glomerular capillary wall as early as 24 hours after PAN. Further studies of altered glomerular permeability may use these sensitive measures to more precisely define the temporal sequence and elucidate possible subgroups of experimental glomerular injury.


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C. Hjalmarsson, M. Ohlson, and B. Haraldsson
Puromycin aminonucleoside damages the glomerular size barrier with minimal effects on charge density
Am J Physiol Renal Physiol, September 1, 2001; 281(3): F503 - F512.
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Copyright © 1984 by the American Society for Investigative Pathology.