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American Journal of Pathology, Vol 117, 441-450, Copyright © 1984 by American Society for Investigative Pathology

REGULAR ARTICLES

Monocyte/macrophage-specific monoclonal antibody Ki-M1 recognizes interdigitating reticulum cells

HJ Radzun, MR Parwaresch, AC Feller and ML Hansmann

A monoclonal antibody, Ki-M1, was produced, and its immunoreactivity was tested by light and electron-microscopic immunohistochemistry. Ki- M1 was found to react with monocytes, cells of the mononuclear phagocyte system (MPS), interdigitating reticulum cells (IDC), and the so-called indeterminate dendritic cells of lymphoid tissue. No reactivity was seen in other human tissues or other hematopoietic cells, including granulocytes and cells of the unstimulated promyelocyte cell line HL-60. Thus, Ki-M1 is the first of the monoclonal antibodies to MPS cells to react with both human IDC and MPS cells. This suggests that IDC and MPS cells may have a common cytogenesis.




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Copyright © 1984 by the American Society for Investigative Pathology.