help button home button Am J Pathol R & D Systems
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Renkonen, R.
Right arrow Articles by Hayry, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Renkonen, R.
Right arrow Articles by Hayry, P.

American Journal of Pathology, Vol 117, 462-470, Copyright © 1984 by American Society for Investigative Pathology

REGULAR ARTICLES

Bone marrow transplantation in the rat. I. Histologic correlations and quantitation of cellular infiltrates in acute graft-versus-host disease

R Renkonen and P Hayry

In an attempt to define which cytologic manifestations of inflammation are characteristic of acute graft-versus-host disease (aGVHD), the authors have analyzed hematologic reconstitution in the bone marrow, spleen, and blood of bone marrow transplant recipients and correlated these events to concomitant cytologic changes in the parenchymal target organs. After bone marrow transplantation from Lewis to BN strain, the strongest inflammatory changes were observed in the liver, a "model" parenchymal target organ for aGVHD in this strain combination. The inflammatory episode of the aGVHD in the liver was characterized by an early lymphoid blastogenesis, the presence of large granular lymphocytes (LGLs), lymphocytosis, and some monocytosis, lacking or significantly less prominent in the liver of syngeneic BN to BN recipients. Concomitantly with the infiltration of the liver with LGLs and lymphocytes, these cells were depleted from blood; and with their disappearance from the liver, they appeared in the recipient spleen. Lack of lymphoid blastogenesis in the bone marrow of allograft recipients and similar though less prominent cytologic changes in the syngeneic graft recipients, make it difficult to differentiate aGVHD- associated changes from normal reconstitution in the lymphoid tissue paper; the minimal changes in the blood make this organ the least suitable site for the monitoring of the aGVHD in the rat.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1984 by the American Society for Investigative Pathology.