This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Virji, M. A. Articles by Rao, K. N. Search for Related Content PubMed PubMed Citation Articles by Virji, M. A. Articles by Rao, K. N.

American Journal of Pathology, Vol 118, 162-167, Copyright © 1985 by American Society for Investigative Pathology

REGULAR ARTICLES

Acute hemorrhagic pancreatitis in mice: A study of glucoregulatory hormones and glucose metabolism

MA Virji and KN Rao

In mice fed a choline-deficient diet containing 0.5% DL-ethionine (CDE) profound hypoglycemia develops, as do signs of shock, and the mice die of acute hemorrhagic pancreatitis (AHP). When fed a choline- supplemented diet containing 0.5% DL-ethionine (CSE), however, the mice have a chronic nonhemorrhagic pancreatitis with focal necrosis, do not show symptoms of shock, and survive. For investigation of the mechanism of hypoglycemia and the onset of shock in AHP, serum and pancreatic insulin and glucagon contents, serum glucose levels, and the morphologic characteristics of pancreatic islets were evaluated in mice fed laboratory Chow (LC); a choline-supplemented (CS) diet; a choline- deficient (CD) diet; or the CSE and CDE diets for 1, 2, or 3 days. The results indicate that onset of shock in animals with AHP may be due to hypoglycemia resulting from abnormal release of glucoregulatory hormones and their inability to maintain glucose output from liver and/or caused by active proteinases released from necrotic pancreas.