This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Johnston, Y. E. Articles by Askenase, P. W. Search for Related Content PubMed PubMed Citation Articles by Johnston, Y. E. Articles by Askenase, P. W.

American Journal of Pathology, Vol 118, 26-34, Copyright © 1985 by American Society for Investigative Pathology

REGULAR ARTICLES

Lyme arthritis. Spirochetes found in synovial microangiopathic lesions

YE Johnston, PH Duray, AC Steere, M Kashgarian, J Buza, SE Malawista and PW Askenase

In 17 patients with Lyme disease, synovial specimens, obtained by synovectomy or needle biopsy, showed nonspecific villous hypertrophy, synovial cell hyperplasia, prominent microvasculature, lymphoplasmacellular infiltration, and sometimes lymphoid follicles. The larger surgically obtained specimens also showed striking deposition of fibrin in synovial stroma and a form of endarteritis obliterans. In 2 patients, spirochetes were seen in and around blood vessels by the Dieterle silver stain. Compared with 55 cases of other synovial disease, obliterative microvascular lesions were seen only in Lyme synovia, but marked stromal deposition of fibrin seemed nonspecific. These findings imply that the Lyme spirochete may survive for years in affected synovium and may be directly responsible for the microvascular injury.

This article has been cited by other articles:

				M. E. Aguero-Rosenfeld, G. Wang, I. Schwartz, and G. P. Wormser Diagnosis of Lyme Borreliosis Clin. Microbiol. Rev., July 1, 2005; 18(3): 484 - 509. [Abstract] [Full Text] [PDF]

				D. Cadavid, Y. Bai, D. Dail, M. Hurd, K. Narayan, E. Hodzic, S. W. Barthold, and A. R. Pachner Infection and Inflammation in Skeletal Muscle from Nonhuman Primates Infected with Different Genospecies of the Lyme Disease Spirochete Borrelia burgdorferi Infect. Immun., December 1, 2003; 71(12): 7087 - 7098. [Abstract] [Full Text] [PDF]

				D. W. Dorward and R. S. Larson Murine Model for Lymphocytic Tropism by Borrelia burgdorferi Infect. Immun., March 1, 2001; 69(3): 1428 - 1432. [Abstract] [Full Text] [PDF]

				E. Akin, J. Aversa, and A. C. Steere Expression of Adhesion Molecules in Synovia of Patients with Treatment-Resistant Lyme Arthritis Infect. Immun., March 1, 2001; 69(3): 1774 - 1780. [Abstract] [Full Text] [PDF]

				D Taylor-Robinson and A Keat How can a causal role for small bacteria in chronic inflammatory arthritides be established or refuted? Ann Rheum Dis, March 1, 2001; 60(3): 177 - 185. [Full Text] [PDF]

				M. D. McKisic, W. L. Redmond, and S. W. Barthold Cutting Edge: T Cell-Mediated Pathology in Murine Lyme Borreliosis J. Immunol., June 15, 2000; 164(12): 6096 - 6099. [Abstract] [Full Text] [PDF]

				E. Akin, G. L. McHugh, R. A. Flavell, E. Fikrig, and A. C. Steere The Immunoglobulin (IgG) Antibody Response to OspA and OspB Correlates with Severe and Prolonged Lyme Arthritis and the IgG Response to P35 Correlates with Mild and Brief Arthritis Infect. Immun., January 1, 1999; 67(1): 173 - 181. [Abstract] [Full Text] [PDF]

				J. Coburn, L. Magoun, S. C. Bodary, and J. M. Leong Integrins alpha vbeta 3 and alpha 5beta 1 Mediate Attachment of Lyme Disease Spirochetes to Human Cells Infect. Immun., May 1, 1998; 66(5): 1946 - 1952. [Abstract] [Full Text] [PDF]

				J Oksi, H Kalimo, R J Marttila, M Marjamaki, P Sonninen, J Nikoskelainen, and M K Viljanen Intracranial aneurysms in three patients with disseminated Lyme borreliosis: cause or chance association? J. Neurol. Neurosurg. Psychiatry, May 1, 1998; 64(5): 636 - 642. [Abstract] [Full Text] [PDF]