This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by van den Oord, J. J. Articles by Desmet, V. J. Search for Related Content PubMed PubMed Citation Articles by van den Oord, J. J. Articles by Desmet, V. J.

American Journal of Pathology, Vol 118, 266-277, Copyright © 1985 by American Society for Investigative Pathology

REGULAR ARTICLES

Immature sinus histiocytosis. Light- and electron-microscopic features, immunologic phenotype, and relationship with marginal zone lymphocytes

JJ van den Oord, C de Wolf-Peeters, R De Vos and VJ Desmet

The light-microscopic, ultrastructural, and immunohistochemical features of immature sinus histiocytosis were studied in 10 lymph nodes with the histologic picture of toxoplasmic lymphadenitis and compared with the features of lymphoid cells present in the marginal zone of the splenic white pulp. Areas of immature sinus histiocytosis consisted largely of medium-sized lymphoid cells with markedly irregular nuclei and abundant pale cytoplasm. Using a panel of monoclonal antibodies, the predominating lymphoid cells were found to carry the B-cell phenotype B1+Ba1-sIgM+sIgD-OKIa1+. Admixed were variable numbers of larger, blastic lymphoid cells, small lymphocytes, histiocytic elements, and polymorphonuclear granulocytes. The marginal zone of the splenic white pulp was composed of a similar mixture of cells, and marginal-zone lymphocytes demonstrated an analogous immunohistochemical phenotype. Our results indicate that immature sinus histiocytes are B- lymphoid cells that are closely related to marginal zone lymphocytes. As such, immature sinus histiocytes may have a role similar to that of marginal-zone lymphocytes, which have been claimed to transport antigens or immune complexes toward the follicular center or to serve as precursors of plasma cells. We suggest that immature sinus histiocytosis represents an abnormal expansion of the marginal zone, normally present at the sinusoidal pole of lymphoid follicles. The reason for this marginal-zone hyperplasia, recognized as immature sinus histiocytosis in a variety of reactive lymph node conditions, may be a maturation arrest in the normal development of immature sinus histiocytes into small, sIgM+ sIgD+ lymphocytes.

This article has been cited by other articles:

				F. I. Camacho, J. F. Garcia, L. Sanchez-Verde, A. I. Saez, M. Sanchez-Beato, M. Mollejo, and M. A. Piris Unique Phenotypic Profile of Monocytoid B Cells : Differences in Comparison with the Phenotypic Profile Observed in Marginal Zone B Cells and So-Called Monocytoid B Cell Lymphoma Am. J. Pathol., April 1, 2001; 158(4): 1363 - 1369. [Abstract] [Full Text] [PDF]

				K. Stein, M. Hummel, P. Korbjuhn, H.-D. Foss, I. Anagnostopoulos, T. Marafioti, and H. Stein Monocytoid B Cells Are Distinct From Splenic Marginal Zone Cells and Commonly Derive From Unmutated Naive B Cells and Less Frequently From Postgerminal Center B Cells by Polyclonal Transformation Blood, October 15, 1999; 94(8): 2800 - 2808. [Abstract] [Full Text] [PDF]

				A. Tierens, J. Delabie, L. Michiels, P. Vandenberghe, and C. De Wolf-Peeters Marginal-Zone B Cells in the Human Lymph Node and Spleen Show Somatic Hypermutations and Display Clonal Expansion Blood, January 1, 1999; 93(1): 226 - 234. [Abstract] [Full Text] [PDF]

				U. Klein, R. Kuppers, and K. Rajewsky Evidence for a Large Compartment of IgM-Expressing Memory B Cells in Humans Blood, February 15, 1997; 89(4): 1288 - 1298. [Abstract] [Full Text] [PDF]