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American Journal of Pathology, Vol 119, 44-56, Copyright © 1985 by American Society for Investigative Pathology

REGULAR ARTICLES

Cellular differentiation of epithelioid sarcoma. An electron- microscopic, enzyme-histochemical, and immunohistochemical study

M Mukai, C Torikata, H Iri, H Hanaoka, T Kawai, K Yakumaru, T Shimoda, A Mikata and K Kageyama

For the purpose of clarifying cellular differentiation of epithelioid sarcoma, studies based on various methods were performed. Enzyme histochemical studies showed that epithelioid sarcoma tumor cells have characteristics intermediate between epithelial cells and the large plump cells of synovial sarcoma-incomplete epithelial differentiation. For alkaline phosphatase and adenosine triphosphatase particularly, positive cells and negative cells coexisted, as in the large plump cells of synovial sarcoma. Immunohistochemical studies for alpha 1- antitrypsin, alpha 1-antichymotrypsin, vimentin, and keratin also showed that epithelioid sarcoma tumor cells are very similar to the large plump cells of synovial sarcoma and have incomplete epithelial differentiation. For example, the examinations of serial sections and double staining methods revealed that keratin-positive cells are always vimentin-positive in epithelioid sarcoma and in the monophasic area of synovial sarcoma. Electron-microscopically, bundles of intermediate filaments and filopodia toward the intercellular lumen were observed, as in the monophasic area of synovial sarcoma. The results of enzyme- histochemical and immunohistochemical studies of non-neoplastic synovial lining cells, performed here for the first time, are also discussed.




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Copyright © 1985 by the American Society for Investigative Pathology.