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American Journal of Pathology, Vol 120, 1-5, Copyright © 1985 by American Society for Investigative Pathology

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Tobacco constituents are mitogenic for arterial smooth-muscle cells

CG Becker, DP Hajjar and JM Hefton

Tobacco glycoprotein (TGP) purified from flue-cured tobacco leaves, tar- derived material (TAR), the water soluble, nondialyzable, delipidized extract of cigarette smoke condensate, rutin-bovine serum albumin conjugates, quercetin, and chlorogenic acid are mitogenic for bovine aortic smooth-muscle cells, but not adventitial fibroblasts. The mitogenicity appears to depend on polyphenol epitopes on carrier molecules. Ellagic acid, another plant polyphenol, inhibited arterial smooth-muscle proliferation. These results suggest that a number of ubiquitous, plant-derived substances may influence smooth-muscle cell proliferation in the arterial wall.

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