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American Journal of Pathology, Vol 120, 327-332, Copyright © 1985 by American Society for Investigative Pathology

REGULAR ARTICLES

Heparin-binding fragments of fibronectin are potent inhibitors of endothelial cell growth

GA Homandberg, JE Williams, D Grant, B Schumacher and R Eisenstein

Two heparin-binding proteolytic fragments of fibronectin--an amino- terminal 29-kd segment and a carboxyl-terminal 40-kd segment-are apparently specific, potent inhibitors of the growth of cultured bovine aortic endothelial cells and inhibit growth in a reversible, dose- dependent manner. In contrast, native fibronectin at higher dosages neither inhibits nor interferes with the effects of the 29-kd fragment. The data, therefore, suggest that fibronectin fragments may participate in the regulation of vascular growth.


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