Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms

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Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms

RP Custer, GC Bosma and MJ Bosma

Histologic findings in mice with severe combined immunodeficiency (SCID) were remarkably uniform, consisting of lymphopenia, a rudimentary thymic medulla without cortex, relatively empty splenic follicles and lymph nodes, and undeveloped bronchial and gastrointestinal lymphocytic foci. Fluorescence-activated cell sorter studies revealed a few T cells (apparently nonfunctional) in thymus and spleen; interestingly, these cells seemed highly disposed to neoplasia, because thymic T-cell lymphomas were observed in 41 of 269 mice. No pre- B or B cells could be identified. Cells of the myeloid lineage appeared normal. Reconstitution of lymphoid tissues was achieved after intravenous injection of histocompatible bone marrow cells.

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				M. F. Cesta Normal Structure, Function, and Histology of the Spleen Toxicol Pathol, August 1, 2006; 34(5): 455 - 465. [Abstract] [Full Text] [PDF]

				E. Piovan, V. Tosello, S. Indraccolo, A. Cabrelle, I. Baesso, L. Trentin, R. Zamarchi, H. Tamamura, N. Fujii, G. Semenzato, et al. Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation Blood, February 1, 2005; 105(3): 931 - 939. [Abstract] [Full Text] [PDF]

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				L. E. Perryman Molecular Pathology of Severe Combined Immunodeficiency in Mice, Horses, and Dogs Vet. Pathol., March 1, 2004; 41(2): 95 - 100. [Abstract] [Full Text] [PDF]

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				C. J. Williams, I. Grandal, D. J. Vesprini, U. Wojtyra, J. S. Danska, and C. J. Guidos Irradiation Promotes V(D)J Joining and RAG-Dependent Neoplastic Transformation in SCID T-Cell Precursors Mol. Cell. Biol., January 15, 2001; 21(2): 400 - 413. [Abstract] [Full Text]

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				E. Goto, H. Kohrogi, N. Hirata, K. Tsumori, S. Hirosako, J. Hamamoto, K. Fujii, O. Kawano, and M. Ando Human Bronchial Intraepithelial T Lymphocytes as a Distinct T-Cell Subset . Their Long-Term Survival in SCID-Hu Chimeras Am. J. Respir. Cell Mol. Biol., April 1, 2000; 22(4): 405 - 411. [Abstract] [Full Text]

				C. Wang, M. A. Bogue, A. P. Nguyen, and D. B. Roth Irradiation-Induced Rescue of Thymocyte Differentiation and V(D)J Recombination in Mice Lacking the Catalytic Subunit of DNA-Dependent Protein Kinase J. Immunol., December 1, 1999; 163(11): 6065 - 6071. [Abstract] [Full Text] [PDF]

				J. A. Taylor, K. Tewari, S. Y. Liao, C. C.�W. Hughes, and L. P. Villarreal Immunohistochemical Analysis, Human Papillomavirus DNA Detection, Hormonal Manipulation, and Exogenous Gene Expression of Normal and Dysplastic Human Cervical Epithelium in Severe Combined Immunodeficiency Mice J. Virol., June 1, 1999; 73(6): 5144 - 5148. [Abstract] [Full Text]

				G. C.M. Smith and S. P. Jackson The DNA-dependent protein kinase Genes & Dev., April 15, 1999; 13(8): 916 - 934. [Full Text]

REGULAR ARTICLES

Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms

				A. Kurimasa, H. Ouyang, L.-j. Dong, S. Wang, X. Li, C. Cordon-Cardo, D. J. Chen, and G. C. Li Catalytic subunit of DNA-dependent protein kinase: Impact on lymphocyte development and tumorigenesis PNAS, February 16, 1999; 96(4): 1403 - 1408. [Abstract] [Full Text] [PDF]

				G. M. Winslow, E. Yager, K. Shilo, D. N. Collins, and F. K. Chu Infection of the Laboratory Mouse with the Intracellular Pathogen Ehrlichia chaffeensis Infect. Immun., August 1, 1998; 66(8): 3892 - 3899. [Abstract] [Full Text] [PDF]

				E. Dahlen, K. Dawe, L. Ohlsson, and G. Hedlund Dendritic Cells and Macrophages Are the First and Major Producers of TNF-{alpha} in Pancreatic Islets in the Nonobese Diabetic Mouse J. Immunol., April 1, 1998; 160(7): 3585 - 3593. [Abstract] [Full Text] [PDF]

				C J Guidos, C J Williams, I Grandal, G Knowles, M T Huang, and J S Danska V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes & Dev., August 15, 1996; 10(16): 2038 - 2054. [Abstract] [PDF]

				M. Lovik The SCID mouse as a model in immunotoxicology Human and Experimental Toxicology, January 1, 1995; 14(1): 126 - 131. [PDF]

				J. McCune, R Namikawa, H Kaneshima, L. Shultz, M Lieberman, and I. Weissman The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function Science, September 23, 1988; 241(4873): 1632 - 1639. [Abstract] [PDF]

				A. E. Stephen, P. T. Masiakos, D. L. Segev, J. P. Vacanti, P. K. Donahoe, and D. T. MacLaughlin Tissue-engineered cells producing complex recombinant proteins inhibit ovarian cancer in vivo PNAS, March 13, 2001; 98(6): 3214 - 3219. [Abstract] [Full Text] [PDF]