This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hansson, G. K. Articles by Reidy, M. A. Search for Related Content PubMed PubMed Citation Articles by Hansson, G. K. Articles by Reidy, M. A.

American Journal of Pathology, Vol 121, 123-127, Copyright © 1985 by American Society for Investigative Pathology

REGULAR ARTICLES

Aortic endothelial cell death and replication in normal and lipopolysaccharide-treated rats

GK Hansson, S Chao, SM Schwartz and MA Reidy

Endothelial cell death and replication was analyzed in the rat aorta with the use of combined IgG immunocytochemistry and 3H-thymidine autoradiography. Dead and replicating cells were clustered in the aortic endothelium of normal rats with a low level of spontaneous cell death and replication. Death and replication were also clustered in rats treated with endotoxin (Escherichia coli lipopolysaccharide [LPS]), a substance which is cytotoxic to endothelial cells in culture. LPS caused a dramatic increase both in endothelial cell death and replication, while no endothelial denudation could be discerned with the use of the 111In-labeled platelet technique. We conclude that endothelial cell death and replication are topographically clustered phenomena, which may imply that cell death leads to a local stimulation of cell replication. Furthermore, LPS induces a massive cell death, which is paralleled by cell replication, yet does not cause any significant increase in denudation. This suggests that the primary effect of LPS on the vessel wall is its cytotoxicity for endothelial cells. Endothelial cell death appears to provide the stimulus for cell replication both in normal and in LPS-treated rats.

This article has been cited by other articles:

				S. M. Schwartz, Z. S. Galis, M. E. Rosenfeld, and E. Falk Plaque Rupture in Humans and Mice Arterioscler. Thromb. Vasc. Biol., April 1, 2007; 27(4): 705 - 713. [Abstract] [Full Text] [PDF]

				M. Feletou and P. M. Vanhoutte Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture) Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H985 - H1002. [Abstract] [Full Text] [PDF]

				X.-A. Li, L. Guo, J. L. Dressman, R. Asmis, and E. J. Smart A Novel Ligand-independent Apoptotic Pathway Induced by Scavenger Receptor Class B, Type I and Suppressed by Endothelial Nitric-oxide Synthase and High Density Lipoprotein J. Biol. Chem., May 13, 2005; 280(19): 19087 - 19096. [Abstract] [Full Text] [PDF]

				T. Bombeli, A. Karsan, J. F. Tait, and J. M. Harlan Apoptotic Vascular Endothelial Cells Become Procoagulant Blood, April 1, 1997; 89(7): 2429 - 2442. [Abstract] [Full Text] [PDF]

				S. Rangaswamy, M. S. Penn, G. M. Saidel, and G. M. Chisolm Exogenous Oxidized Low-Density Lipoprotein Injures and Alters the Barrier Function of Endothelium in Rats In Vivo Circ. Res., January 1, 1997; 80(1): 37 - 44. [Abstract] [Full Text]