help button home button Am J Pathol ASIP WHAT IS IT?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cattell, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cattell, V.

American Journal of Pathology, Vol 121, 88-95, Copyright © 1985 by American Society for Investigative Pathology

REGULAR ARTICLES

Mitomycin-induced hemolytic uremic kidney. An experimental model in the rat

V Cattell

Hemolytic uremic syndrome (HUS) reported in some patients treated for cancer with mitomycin is of unknown pathogenesis, and evidence implicating mitomycin is inconclusive. To determine whether mitomycin can induce direct renal damage, left kidneys in Lewis rats were perfused with mitomycin (60-4000 micrograms). Control rats received perfusions of saline only. Renal tissue was examined from 1 hour up to 1 month later. In 29 of 31 rats left renal disease developed: in 9 (mitomycin, 1000-4000 micrograms), severe cortical infarction; in 20 (mitomycin, 60-500 micrograms), lesions indistinguishable from human HUS. Glomerular endothelial damage was the earliest detectable abnormality, followed by platelet accumulation and later capillary wall splitting typical of microangiopathy. Some kidneys had interlobular artery necrosis and thrombosis. Right kidneys were normal. In no rats in the control group (10) did HUS develop. Thus, mitomycin directly produced renal lesions indistinguishable from human HUS, which suggested a mechanism for injury seen in mitomycin-treated patients and provided a new model of HUS.


This article has been cited by other articles:


Home page
 Toxicol PatholHome page
Y. Ramot and A. Nyska
Drug-Induced Thrombosis--Experimental, Clinical, and Mechanistic Considerations
Toxicol Pathol, February 1, 2007; 35(2): 208 - 225.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
D. Kavanagh, T. H. J. Goodship, and A. Richards
Atypical haemolytic uraemic syndrome
Br. Med. Bull., October 5, 2006; (2006) ldl004v2.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by the American Society for Investigative Pathology.