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American Journal of Pathology, Vol 121, 497-504, Copyright © 1985 by American Society for Investigative Pathology

REGULAR ARTICLES

Virus persists in beta cells of islets of Langerhans and infection is associated with chemical manifestations of diabetes. II. Morphologic observations

M Rodriguez, RS Garrett, M Raitt, PW Lampert and MB Oldstone

Persistence of lymphocytic choriomeningitis (LCM) virus in the islets of Langerhans was associated with mild hyperglycemia and abnormal glucose tolerance test results. Early histopathologic events consisted of occasional perivascular inflammatory mononuclear cells around both islet and acinar cells. Morphometric studies showed an increase in the size of islets from virus-infected mice. By electron microscopy, LCM virions were found within infected beta cells. Cytolytic injury of beta cells was minimal and did not account for the abnormalities of glucose metabolism. In contrast to the findings in islets, ultrastructural studies of acinar cells revealed LCM virions in abundance, vacuolar degeneration, and intracytoplasmic inclusions. This study extends the previous observation that LCM virus infection may persist in beta cells of the islets of Langerhans without causing structural injury but be associated with abnormalities resembling the chemical and histopathologic features of the early stage of Type II (adult-onset) human diabetes mellitus.


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M. Flodstrom, D. Tsai, C. Fine, A. Maday, and N. Sarvetnick
Diabetogenic Potential of Human Pathogens Uncovered in Experimentally Permissive {beta}-Cells
Diabetes, August 1, 2003; 52(8): 2025 - 2034.
[Abstract] [Full Text] [PDF]


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Copyright © 1985 by the American Society for Investigative Pathology.