help button home button Am J Pathol Angiogenesis Meeting
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Silver, M. M.
Right arrow Articles by Hodsman, A. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Silver, M. M.
Right arrow Articles by Hodsman, A. B.

American Journal of Pathology, Vol 122, 17-27, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

Renal and systemic kappa light chain deposits and their plasma cell origin identified by immunoelectron microscopy

MM Silver, SA Hearn, S Ritchie, RP Slinger, JA Sholdice, PS Cordy and AB Hodsman

Kappa light chain determinants were identified by immunoelectron microscopy in nodular glomerulosclerotic lesions and systemic interstitial deposits from a man who died several years after the onset of proteinuric renal failure treated by hemodialysis. He developed adrenal and hepatic failure preterminally but not overt malignant myeloma. Specific labeling was most concentrated over the inner aspect of glomerular basement membrane and the mesangium, which suggested that the protein was nonfiltrable. Tubular basement membrane labeling was densest over the outer aspect, which suggested that the protein perfused from the interstitium rather than from the tubular lumen. We identified the source of the protein as a population of plasma cells present within bone marrow and renal interstitium; these showed specific immunogold labeling for kappa light chain protein over organelles concerned with protein synthesis, secretion, and storage. This appears to be the first identification of light chain determinants in human interstitial para-amyloid deposits with the use of immunogold ultrastructural techniques in tissues prepared for electron microscopy by standard methods and stored as epoxy resin blocks.


This article has been cited by other articles:


Home page
 BloodHome page
A. Lebeau, E. Zeindl-Eberhart, E.-C. Muller, J. Muller-Hocker, P. R. Jungblut, B. Emmerich, and U. Lohrs
Generalized crystal-storing histiocytosis associated with monoclonal gammopathy: molecular analysis of a disorder with rapid clinical course and review of the literature
Blood, August 13, 2002; 100(5): 1817 - 1827.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
M. J. Ansari, A. Kumar, and J. Turney
Light from the renal biopsy
Nephrol. Dial. Transplant., September 1, 2001; 16(9): 1945 - 1946.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the American Society for Investigative Pathology.