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American Journal of Pathology, Vol 122, 199-203, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

L&H variants of Reed-Sternberg cells express sialylated Leu M1 antigen

SM Hsu, YS Ho, PJ Li, J Monheit, HJ Ree, K Sheibani and CD Winberg

Anti-Leu M1 generally does not stain the lymphocytic and histiocytic (L&H) variants of Reed-Sternberg cells in the lymphocyte predominant type of Hodgkin's disease. However, the authors found that after neuraminidase treatment for removal of sialic acid, the L&H cells in more than half of the cases studied could be stained by anti-Leu M1. This result strongly suggests that L&H cells differ from the Reed- Sternberg cells in other types of Hodgkin's disease in their unique capacity to sialylate the 150-kd Leu M1 antigen.




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Copyright © 1986 by the American Society for Investigative Pathology.