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American Journal of Pathology, Vol 122, 433-442, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

Immunohistochemical localization of neurofilaments and neuron-specific enolase in 29 cases of neuroblastoma

M Osborn, T Dirk, H Kaser, K Weber and M Altmannsberger

Twenty-nine neuroblastomas have been examined with the use of rabbit antibodies specific for each of the three neurofilament polypeptides, with a monoclonal antibody specific for the NF-L polypeptide, and with a rabbit antibody specific for neuron-specific enolase. When frozen material was used, all neuroblastomas were positive with the neurofilaments antibodies. When alcohol-fixed paraffin-embedded material was used, neurofilament staining was weaker and the fixation procedure appeared to destroy the epitopes recognized by the NF-L antibodies preferentially. Although all neuroblastomas were positive for neurone-specific enolase, so were two rhabdomyosarcomas, suggesting that NSE is not an appropriate marker to distinguish the different small blue cell tumors of children.


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Copyright © 1986 by the American Society for Investigative Pathology.