This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chatelet, F. Articles by Verroust, P. Search for Related Content PubMed PubMed Citation Articles by Chatelet, F. Articles by Verroust, P.

American Journal of Pathology, Vol 122, 500-511, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. I. Renal distribution

F Chatelet, E Brianti, P Ronco, J Roland and P Verroust

The authors have previously reported the production of monoclonal anti- brush border antibodies defining two glycoprotein (gp) antigens of 90 and 330 kd which are also expressed on glomerular cells and may thus be of significance for in situ formation of immune complexes. The 330-kd antigen is involved in Heymann's nephritis, whereas the 90-kd antigen induces transient glomerular immune deposits. In this report, the authors describe the renal ultrastructural localization of the two antigens, which are both detectable on brush border and glomerular epithelial cells but assume contrasting patterns: gp 90 is diffusely present on the cell membranes, whereas gp 330 is concentrated in the intermicrovillar region and within the coated pits. Their localization within proximal tubular cells, on the membrane of intracytoplasmic vesicles, suggests that they are involved in endocytosis. In addition, gp 90 is expressed on endothelial cells lining glomerular capillaries. These observations may help us to understand the formation and different kinetics of immune glomerular deposits.

This article has been cited by other articles:

				H. Birn The kidney in vitamin B12 and folate homeostasis: characterization of receptors for tubular uptake of vitamins and carrier proteins Am J Physiol Renal Physiol, July 1, 2006; 291(1): F22 - F36. [Abstract] [Full Text] [PDF]

				K. Faber, V. Hvidberg, S. K. Moestrup, B. Dahlback, and L. B. Nielsen Megalin Is a Receptor for Apolipoprotein M, and Kidney-Specific Megalin-Deficiency Confers Urinary Excretion of Apolipoprotein M Mol. Endocrinol., January 1, 2006; 20(1): 212 - 218. [Abstract] [Full Text] [PDF]

				P. Ronco and H. Debiec Molecular Pathomechanisms of Membranous Nephropathy: From Heymann Nephritis to Alloimmunization J. Am. Soc. Nephrol., May 1, 2005; 16(5): 1205 - 1213. [Abstract] [Full Text] [PDF]

				M. Nagai, T. Meerloo, T. Takeda, and M. G. Farquhar The Adaptor Protein ARH Escorts Megalin to and through Endosomes Mol. Biol. Cell, December 1, 2003; 14(12): 4984 - 4996. [Abstract] [Full Text] [PDF]

				A. Saito, J. J. Kazama, N. Iino, K. Cho, N. Sato, H. Yamazaki, Y. Oyama, T. Takeda, R. A. Orlando, F. Shimizu, et al. Bioengineered Implantation of Megalin-Expressing Cells: A Potential Intracorporeal Therapeutic Model for Uremic Toxin Protein Clearance in Renal Failure J. Am. Soc. Nephrol., August 1, 2003; 14(8): 2025 - 2032. [Abstract] [Full Text] [PDF]

				E. I. Christensen and H. Birn Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule Am J Physiol Renal Physiol, April 1, 2001; 280(4): F562 - F573. [Abstract] [Full Text] [PDF]

				H. BIRN, H. VORUM, P. J. VERROUST, S. K. MOESTRUP, and E. I. CHRISTENSEN Receptor-Associated Protein Is Important for Normal Processing of Megalin in Kidney Proximal Tubules J. Am. Soc. Nephrol., February 1, 2000; 11(2): 191 - 202. [Abstract] [Full Text] [PDF]

				S. MARUYAMA, E. CANTU III, C. DEMARTINO, A. VLADUTIU, P. R. B. CALDWELL, C. Y. WANG, V. D'AGATI, G. GODMAN, D. M. STERN, and G. ANDRES Membranous Glomerulonephritis Induced in the Pig by Antibody to Angiotensin-Converting Enzyme: Considerations on Its Relevance to thePathogenesis of Human Idiopathic Membranous Glomerulonephritis J. Am. Soc. Nephrol., October 1, 1999; 10(10): 2102 - 2108. [Abstract] [Full Text]

				E. I. CHRISTENSEN and T. E. WILLNOW Essential Role of Megalin in Renal Proximal Tubule for Vitamin Homeostasis J. Am. Soc. Nephrol., October 1, 1999; 10(10): 2224 - 2236. [Full Text]

				R. Czekay, R. Orlando, L Woodward, E. Adamson, and M. Farquhar The expression of megalin (gp330) and LRP diverges during F9 cell differentiation J. Cell Sci., January 4, 1995; 108(4): 1433 - 1441. [Abstract] [PDF]