This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mathan, M. M. Articles by Mathan, V. I. Search for Related Content PubMed PubMed Citation Articles by Mathan, M. M. Articles by Mathan, V. I.

American Journal of Pathology, Vol 123, 25-38, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

Ultrastructural pathology of the rectal mucosa in Shigella dysentery

MM Mathan and VI Mathan

Colonocyte damage in the rectal mucosa in shigellosis is the result of bacterial invasion and leads to ulceration. Additional factors in colonocyte damage may be the Shigella cytotoxin and, especially in colonic crypt cells, bacterial endotoxin. A vascular lesion was present in the lamina propria of the rectal mucosa, which resembled endothelial damage secondary to bacterial endotoxins. In patients with longer duration of symptoms, relative vascular insufficiency, activated lymphocytes, eosinophil and mast cell degranulation, and antibody- mediated colonocyte damage may all play a role.

This article has been cited by other articles:

				Y. H. Liu, X. S. Piao, D. Y. Ou, Y. H. Cao, D. S. Huang, and D. F. Li Effects of Particle Size and Physical Form of Diets on Mast Cell Numbers, Histamine, and Stem Cell Factor Concentration in the Small Intestine of Broiler Chickens Poult. Sci., December 1, 2006; 85(12): 2149 - 2155. [Abstract] [Full Text] [PDF]

				M. J Rahman, P. Sarker, S. K Roy, S. M Ahmad, J. Chisti, T. Azim, M. Mathan, D. Sack, J. Andersson, and R. Raqib Effects of zinc supplementation as adjunct therapy on the systemic immune responses in shigellosis Am. J. Clinical Nutrition, February 1, 2005; 81(2): 495 - 502. [Abstract] [Full Text] [PDF]

				J. F. Koterski, M. Nahvi, M. M. Venkatesan, and B. Haimovich Virulent Shigella flexneri Causes Damage to Mitochondria and Triggers Necrosis in Infected Human Monocyte-Derived Macrophages Infect. Immun., January 1, 2005; 73(1): 504 - 513. [Abstract] [Full Text] [PDF]

				R. Raqib, P. K. Moly, P. Sarker, F. Qadri, N. H. Alam, M. Mathan, and J. Andersson Persistence of Mucosal Mast Cells and Eosinophils in Shigella-Infected Children Infect. Immun., May 1, 2003; 71(5): 2684 - 2692. [Abstract] [Full Text] [PDF]

				R. Raqib, C. Ekberg, P. Sharkar, P. K. Bardhan, A. Zychlinsky, P. J. Sansonetti, and J. Andersson Apoptosis in Acute Shigellosis Is Associated with Increased Production of Fas/Fas Ligand, Perforin, Caspase-1, and Caspase-3 but Reduced Production of Bcl-2 and Interleukin-2 Infect. Immun., June 1, 2002; 70(6): 3199 - 3207. [Abstract] [Full Text] [PDF]

				H. Kohler, S. P. Rodrigues, and B. A. McCormick Shigella flexneri Interactions with the Basolateral Membrane Domain of Polarized Model Intestinal Epithelium: Role of Lipopolysaccharide in Cell Invasion and in Activation of the Mitogen-Activated Protein Kinase ERK Infect. Immun., March 1, 2002; 70(3): 1150 - 1158. [Abstract] [Full Text] [PDF]

				C. Wenneras, P. Ave, M. Huerre, J. Arondel, R. Ulevitch, J. Mathison, and P. Sansonetti Blockade of CD14 aggravates experimental shigellosis Innate Immunity, December 1, 2001; 7(6): 442 - 446. [Abstract] [PDF]

				R. Raqib, S. M. S. Mia, F. Qadri, T. I. Alam, N. H. Alam, A. K. Chowdhury, M. M. Mathan, and J. Andersson Innate Immune Responses in Children and Adults with Shigellosis Infect. Immun., June 1, 2000; 68(6): 3620 - 3629. [Abstract] [Full Text] [PDF]

				C. Wenneras, P. Ave, M. Huerre, J. Arondel, R. J. Ulevitch, J. C. Mathison, and P. Sansonetti Blockade of CD14 Increases Shigella-Mediated Invasion and Tissue Destruction J. Immunol., March 15, 2000; 164(6): 3214 - 3221. [Abstract] [Full Text] [PDF]

				W. L. Beatty, S. Meresse, P. Gounon, J. Davoust, J. Mounier, P. J. Sansonetti, and J.-P. Gorvel Trafficking of Shigella Lipopolysaccharide in Polarized Intestinal Epithelial Cells J. Cell Biol., May 17, 1999; 145(4): 689 - 698. [Abstract] [Full Text] [PDF]

				S. Hossain, R. Biswas, I. Kabir, S. Sarker, M. Dibley, G. Fuchs, and D. Mahalanabis Single dose vitamin A treatment in acute shigellosis in Bangladeshi children: randomised double blind controlled trial BMJ, February 7, 1998; 316(7129): 422 - 426. [Abstract] [Full Text]

				A. Cersini, A. M. Salvia, and M. L. Bernardini Intracellular Multiplication and Virulence of Shigella flexneri Auxotrophic Mutants Infect. Immun., February 1, 1998; 66(2): 549 - 557. [Abstract] [Full Text] [PDF]