This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tenner-Racz, K. Articles by Popovic, M. Search for Related Content PubMed PubMed Citation Articles by Tenner-Racz, K. Articles by Popovic, M.

American Journal of Pathology, Vol 123, 9-15, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

HTLV-III/LAV viral antigens in lymph nodes of homosexual men with persistent generalized lymphadenopathy and AIDS

K Tenner-Racz, P Racz, M Bofill, A Schulz-Meyer, M Dietrich, P Kern, J Weber, AJ Pinching, F Veronese-Dimarzo and M Popovic

The presence of core antigens of retrovirus HTLV-III/LAV, referred to as "AIDS-related virus" (AV), has been sought in lymph node samples of patients with persistent generalized lymphadenopathy (PGL, 28 patients), prodromal AIDS (1 patient) and AIDS with Kaposi sarcoma (3 patients). In 30 patients the deposition of viral antigens, detected by monoclonal antibodies to HTLV-III and LAV, could be observed within the germinal centers (GCs) primarily within the extracellular network of immune complexes, and the two patients who were negative were atypical. No AV could be found in normal tonsil or in samples with follicular hyperplasia of unknown etiology (20 cases). These findings, taken together with the ultrastructural identification of typical retrovirus particles in all 9 PGL and 2 AIDS cases studied, indicates that the network of follicular dendritic (FD) cells is an important reservoir of AV virus antigen at this site. The persistence of this retrovirus inside the GCs helps explain how the follicular hyperplasia affecting FD cells and B blasts in PGL may in progressive cases be accompanied by destruction of FD cells and gradual development of T4+ lymphopenia. T4+ T cells may circulate through the GCs and become infected with AV there. In addition, the identification of retrovirus antigen in situ may be of diagnostic value.

This article has been cited by other articles:

				M. Popovic, K. Tenner-Racz, C. Pelser, H.-J. Stellbrink, J. van Lunzen, G. Lewis, V. S. Kalyanaraman, R. C. Gallo, and P. Racz Persistence of HIV-1 structural proteins and glycoproteins in lymph nodes of patients under highly active antiretroviral therapy PNAS, October 11, 2005; 102(41): 14807 - 14812. [Abstract] [Full Text] [PDF]

				L. de Repentigny, D. Lewandowski, and P. Jolicoeur Immunopathogenesis of Oropharyngeal Candidiasis in Human Immunodeficiency Virus Infection Clin. Microbiol. Rev., October 1, 2004; 17(4): 729 - 759. [Abstract] [Full Text] [PDF]

				V Uhlmann, C M Martin, O Sheils, L Pilkington, I Silva, A Killalea, S B Murch, J Walker-Smith, M Thomson, A J Wakefield, et al. Potential viral pathogenic mechanism for new variant inflammatory bowel disease Mol. Pathol., April 1, 2002; 55(2): 84 - 90. [Abstract] [Full Text] [PDF]

				D. H. Margolin, E. F. Helmuth Saunders, B. Bronfin, N. de Rosa, M. K. Axthelm, X. Alvarez, and N. L. Letvin High Frequency of Virus-Specific B Lymphocytes in Germinal Centers of Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys J. Virol., March 19, 2002; 76(8): 3965 - 3973. [Abstract] [Full Text] [PDF]

				B. A. Smith-Franklin, B. F. Keele, J. G. Tew, S. Gartner, A. K. Szakal, J. D. Estes, T. C. Thacker, and G. F. Burton Follicular Dendritic Cells and the Persistence of HIV Infectivity: The Role of Antibodies and Fc{gamma} Receptors J. Immunol., March 1, 2002; 168(5): 2408 - 2414. [Abstract] [Full Text] [PDF]

				L. Kacani, W. M. Prodinger, G. M. Sprinzl, M. G. Schwendinger, M. Spruth, H. Stoiber, S. Döpper, S. Steinhuber, F. Steindl, and M. P. Dierich Detachment of Human Immunodeficiency Virus Type 1 from Germinal Centers by Blocking Complement Receptor Type 2 J. Virol., September 1, 2000; 74(17): 7997 - 8002. [Abstract] [Full Text]

				S. Moir, A. Malaspina, Y. Li, T.-W. Chun, T. Lowe, J. Adelsberger, M. Baseler, L. A. Ehler, S. Liu, R. T. Davey , Jr., et al. B Cells of HIV-1-infected Patients Bind Virions through CD21-Complement Interactions and Transmit Infectious Virus to Activated T Cells J. Exp. Med., August 28, 2000; 192(5): 637 - 646. [Abstract] [Full Text] [PDF]

				M. J. Kuroda, J. E. Schmitz, A. Seth, R. S. Veazey, C. E. Nickerson, M. A. Lifton, P. J. Dailey, M. A. Forman, P. Racz, K. Tenner-Racz, et al. Simian immunodeficiency virus-specific cytotoxic T lymphocytes and cell-associated viral RNA levels in distinct lymphoid compartments of SIVmac-infected rhesus monkeys Blood, August 15, 2000; 96(4): 1474 - 1479. [Abstract] [Full Text] [PDF]

				H. Kuster, M. Opravil, P. Ott, E. Schlaepfer, M. Fischer, H. F. Gunthard, R. Luthy, R. Weber, and R. W. Cone Treatment-Induced Decline of Human Immunodeficiency Virus-1 p24 and HIV-1 RNA in Lymphoid Tissue of Patients with Early Human Immunodeficiency Virus-1 Infection Am. J. Pathol., June 1, 2000; 156(6): 1973 - 1986. [Abstract] [Full Text] [PDF]

				F. Eitner, Y. Cui, G. Grouard-Vogel, K. L. Hudkins, A. Schmidt, T. Birkebak, M. B. Agy, S.-L. Hu, W. R. Morton, D. M. Anderson, et al. Rapid Shift from Virally Infected Cells to Germinal Center-Retained Virus after HIV-2 Infection of Macaques Am. J. Pathol., April 1, 2000; 156(4): 1197 - 1207. [Abstract] [Full Text] [PDF]

				K. Tenner-Racz, H.-J. Stellbrink, J. van Lunzen, C. Schneider, J.-P. Jacobs, B. Raschdorff, G. Grossschupff, R. M. Steinman, and P. Racz The Unenlarged Lymph Nodes of HIV-1-infected, Asymptomatic Patients with High CD4 T Cell Counts Are Sites for Virus Replication and CD4 T Cell Proliferation. The Impact of Highly Active Antiretroviral Therapy J. Exp. Med., March 16, 1998; 187(6): 949 - 959. [Abstract] [Full Text] [PDF]

				G. Pantaleo, S. Menzo, M. Vaccarezza, C. Graziosi, O. J. Cohen, J. F. Demarest, D. Montefiori, J. M. Orenstein, C. Fox, L. K. Schrager, et al. Studies in Subjects with Long-Term Nonprogressive Human Immunodeficiency Virus Infection N. Engl. J. Med., January 26, 1995; 332(4): 209 - 216. [Abstract] [Full Text] [PDF]

				A. Fauci Multifactorial nature of human immunodeficiency virus disease: implications for therapy Science, November 12, 1993; 262(5136): 1011 - 1018. [Abstract] [PDF]

				R. Weiss How does HIV cause AIDS? Science, May 28, 1993; 260(5112): 1273 - 1279. [Abstract] [PDF]

				G. Pantaleo, C. Graziosi, and A. S. Fauci The Immunopathogenesis of Human Immunodeficiency Virus Infection N. Engl. J. Med., February 4, 1993; 328(5): 327 - 335. [Full Text]