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American Journal of Pathology, Vol 123, 250-255, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

Immunoreactive somatostatin in Warthin's tumor

Y Hayashi, H Saito, S Saito, T Yanagawa, H Yoshida, Y Yura and M Sato

The presence of somatostatin (SRIF) in the neoplastic epithelial cells of certain Warthin's tumors arising in the human parotid gland was found immunohistochemically, whereas the other parotid gland tumors, such as pleomorphic adenoma, oxyphilic adenoma, mucoepidermoid tumor, adenocarcinoma, and adenoid cystic carcinoma, did not show positive immunoreactivity for SRIF. The SRIF-positive Warthin's tumor had dense core granules immunoreactive with anti-SRIF serum. Moreover, a comparatively high concentration of immunoreactive SRIF was detected by radioimmunoassay in an SRIF-positive Warthin's tumor, although the other tumors also contained low levels of immunoreactive SRIF.




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Copyright © 1986 by the American Society for Investigative Pathology.