This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Oosterwijk, E. Articles by Warnaar, S. O. Search for Related Content PubMed PubMed Citation Articles by Oosterwijk, E. Articles by Warnaar, S. O.

American Journal of Pathology, Vol 123, 301-309, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

Immunohistochemical analysis of monoclonal antibodies to renal antigens. Application in the diagnosis of renal cell carcinoma

E Oosterwijk, DJ Ruiter, JC Wakka, JW Huiskens-van der Meij, U Jonas, GJ Fleuren, J Zwartendijk, P Hoedemaeker and SO Warnaar

Four mouse monoclonal antibodies reacting with renal proximal epithelium were characterized on normal adult tissues, fetal kidneys, and various malignancies. These four antibodies were found to react with renal cell carcinomas (RCCs) but not with a variety of other tumors. Three antibodies react only with some primary RCCs and not with metastatic RCCs. The fourth antibody, RC 38, reacts with 46 of 47 primary RCCs tested and with 8 of 13 RCC metastases. No reaction was seen with 179 tumors of various origin, which indicates that this antibody is very useful in diagnosing RCC.

This article has been cited by other articles:

				H. Uemura, K. Fujimoto, M. Tanaka, M. Yoshikawa, Y. Hirao, S. Uejima, K. Yoshikawa, and K. Itoh A Phase I Trial of Vaccination of CA9-Derived Peptides for HLA-A24-Positive Patients with Cytokine-Refractory Metastatic Renal Cell Carcinoma. Clin. Cancer Res., March 15, 2006; 12(6): 1768 - 1775. [Abstract] [Full Text] [PDF]