This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Adler, S. Articles by Couser, W. G. Search for Related Content PubMed PubMed Citation Articles by Adler, S. Articles by Couser, W. G.

American Journal of Pathology, Vol 123, 553-562, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

Studies of progressive glomerular sclerosis in the rat

S Adler, LJ Striker, GE Striker, DT Perkinson, J Hibbert and WG Couser

To obtain a better understanding of the sequential development of sclerosis in immune glomerular disease, the authors induced experimental membranous nephropathy in unilaterally nephrectomized rats and evaluated the lesions that developed over a 35-week period. Serial renal biopsies were examined by light and immunofluorescence microscopy for IgG, C3, neoantigens of the membrane attack complex (MAC), and interstitial (Type III) and basement membrane (Type IV) collagen. Urinary protein excretion increased from 208 +/- 19 mg/day to 308 +/- 36 mg/day during the period of observation. Progressive mesangial sclerosis, crescent formation, and interstitial fibrosis developed in association with deposition of Type IV but not Type III collagen in the glomeruli. Capillary wall deposits of IgG, C3, and MAC gradually decreased, whereas coarse granular deposits of C3 and MAC were visible in sclerotic areas beginning at 8 weeks. The appearance of complement components in early sclerotic lesions raises the possibility that they are of pathogenetic importance. The absence of interstitial collagen in sclerotic glomeruli suggests that the components of the lesion are produced solely by glomerular cells.

This article has been cited by other articles:

				R. G.B. Bonegio, R. Fuhro, Z. Wang, C. R. Valeri, C. Andry, D. J. Salant, and W. Lieberthal Rapamycin Ameliorates Proteinuria-Associated Tubulointerstitial Inflammation and Fibrosis in Experimental Membranous Nephropathy J. Am. Soc. Nephrol., July 1, 2005; 16(7): 2063 - 2072. [Abstract] [Full Text] [PDF]

				S. Watanabe, Y. Nagashio, H. Asaumi, Y. Nomiyama, M. Taguchi, M. Tashiro, Y. Kihara, H. Nakamura, and M. Otsuki Pressure activates rat pancreatic stellate cells Am J Physiol Gastrointest Liver Physiol, December 1, 2004; 287(6): G1175 - G1181. [Abstract] [Full Text] [PDF]

				M. Ruperez, M. Ruiz-Ortega, V. Esteban, O. Lorenzo, S. Mezzano, J. J. Plaza, and J. Egido Angiotensin II Increases Connective Tissue Growth Factor in the Kidney Am. J. Pathol., November 1, 2003; 163(5): 1937 - 1947. [Abstract] [Full Text] [PDF]

				S. J. ELLIOT, L. J. STRIKER, W. G. STETLER-STEVENSON, T. A. JACOT, and G. E. STRIKER Pentosan Polysulfate Decreases Proliferation and Net Extracellular Matrix Production in Mouse Mesangial Cells J. Am. Soc. Nephrol., January 1, 1999; 10(1): 62 - 68. [Abstract] [Full Text]

				T. Miralem and D. M. Templeton Inactivation of kinase cascades in mesangial cells grown on collagen type I Am J Physiol Renal Physiol, October 1, 1998; 275(4): F585 - F594. [Abstract] [Full Text] [PDF]