help button home button Am J Pathol R & D Systems
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schuurmans Stekhoven, J. H.
Right arrow Articles by Schretlen, E. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schuurmans Stekhoven, J. H.
Right arrow Articles by Schretlen, E. D.

American Journal of Pathology, Vol 124, 46-52, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

Morphology and incidence of the "posttherapeutic lymphoid cell" in the bone marrow of children with acute lymphoblastic leukemia

JH Schuurmans Stekhoven, CA Langenhuysen, JA Bakkeren, R Holland, I Holler, GA De Vaan and ED Schretlen

In the posttherapeutic bone marrow of a group of 30 children with acute lymphoblastic leukemia (ALL), small numbers of a particular lymphoid cell with a comparatively large size and large dark nucleus were found. This cell was called the "posttherapeutic lymphoid cell." This type of cell is easily distinguishable in the May-Grunwald-Giemsa-stained smears as well as in semi- and ultrathin Epon sections. Immunoelectron- microscopically it proved to be positive for common ALL. It is hypothesized that the cell might be characteristic for ALL. However, it appeared that this cell could equally be found in non-Hodgkin's malignant lymphoma after a treatment comparable to that in ALL. Furthermore, the cell could be detected in the posttherapeutic bone marrow of children with nonlymphoid malignancies as well as the marrow of very young children (under 2 years of age) with nonmalignant diseases. The results showed that the cell in question is not associated with a particular disease but, rather, represents a special type of lymphoid cell in the regenerating or actively proliferating bone marrow.


This article has been cited by other articles:


Home page
 BloodHome page
R. W. McKenna, L. T. Washington, D. B. Aquino, L. J. Picker, and S. H. Kroft
Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry
Blood, October 15, 2001; 98(8): 2498 - 2507.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the American Society for Investigative Pathology.